The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cytogenetics of paediatric and adolescent acute lymphoblastic leukaemia
Open accessAbstract
Summary: Cytogenetics has determined the incidence and prognostic significance of chromosomal abnormalities in acute lymphoblastic leukaemia (ALL). The development of fluorescence in situ hybridization (FISH) and array technologies has led to the discovery of novel aberrations. Five ‘hot topics’ are presented in which cytogenetics and related techniques have been instrumental in understanding the role of genetics in leukaemogenesis: (i) genetic changes are integral to the biology of T‐cell ALL; (ii) intrachromosomal amplification of chromosome 21 is a new recurrent abnormality in precursor‐B ALL (BCP‐ALL); (iii) the immunoglobulin heavy chain gene (IGH@) is significant in BCP‐ALL; (iv) alterations in genes involved in B‐cell development and cell cycle control contribute to the pathogenesis of BCP‐ALL; (v) age‐related cytogenetic profiles define ALL in children and adolescents as distinct biological entities. In this molecular era, cytogenetics continues to be integral to our understanding of the genetics of this disease.
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ROWLEY, J. D. (1973) · Nature · doi:10.1038/243290a0 · Cited by 4,291
Cited by
Inaba, H., Greaves, M., & Mullighan, C. G. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62187-4 · Cited by 1,074
Russell, L. J., Capasso, M., Vater, I., Akasaka, T., Bernard, O. A., Calasanz, M. J., Chandrasekaran, T., Chapiro, E., Gesk, S., Griffiths, M., et al. (2009) · Blood · doi:10.1182/blood-2009-03-208397 · Cited by 498
Self-citationRedefining ALL classification: toward detecting high-risk ALL and implementing precision medicine
Hunger, S. P., & Mullighan, C. G. (2015) · Blood · doi:10.1182/blood-2015-02-580043 · Cited by 292
Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults
Yasuda, T., Tsuzuki, S., Kawazu, M., Hayakawa, F., Kojima, S., Ueno, T., Imoto, N., Kohsaka, S., Kunita, A., Doi, K., et al. (2016) · Nature Genetics · doi:10.1038/ng.3535 · Cited by 265
Molecular genetics of B-precursor acute lymphoblastic leukemia
Mullighan, C. G. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61203 · Cited by 247
Metadata
- Authors
- Harrison, C. J.
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 2008-12-17
- Volume
- 144
- Issue
- 2
- Pages
- 147-156
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W2147262371
- Cited by
- 216
- References
- 1
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.