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Effect of leukotriene D4 on nasal mucosal blood flow, nasal airway resistance and nasal secretion in humans
Abstract
Summary: The possible role of leukotriene D 4(LTD 4)in nasal allergy was investigated in healthy volunteers. Nasal blood flow, nasal airway resistance, nasal discharge and nasal itching and sneezing were examined. LTD 4 was found to induce a dose‐response related increase in nasal mucosal blood flow as measured by laser‐Doppler flowmetry. Histamine exhibited similar effects on blood flow in the same concentration range. Nasal airway resistance as recorded by rhinomanometry, increased in a dose‐related manner after topical LTD 4. Nasal secretion was obtained by nasal lavage and estimated from a dilution principle. Topical LTD 4 did not increase the amount of nasal secretion, whereas a dose‐related increase was found after topical histamine. LTD 4 did not cause itching, sneezing or other irritative symptoms. In conclusion, LTD 4 may play a role in nasal allergy by increasing blood flow and nasal airway resistance. Itching, sneezing and discharge, however, are apparently not caused by LTD 4 but can be accounted for by the release of histamine or other mediators.
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Cited by
DAHLÉN, B., NIZANKOWSKA, E., SZCZEKLIK, A., ZETTERSTRÖM, O., BOCHENEK, G., KUMLIN, M., MASTALERZ, L., PINIS, G., SWANSON, L. J., BOODHOO, T. I., et al. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.4.9707089 · Cited by 396
International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors
Brink, C., Dahlén, S.-E., Drazen, J., Evans, J. F., Hay, D. W. P., Nicosia, S., Serhan, C. N., Shimizu, T., & Yokomizo, T. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.8 · Cited by 286
The correlation between allergic rhinitis and sleep disturbance
Craig, T. J., McCann, J. L., Gurevich, F., & Davies, M. J. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.08.044 · Cited by 148
Influences of Allergic Rhinitis on Sleep
Ferguson, B. J. (2004) · Otolaryngology–Head and Neck Surgery · doi:10.1016/j.otohns.2004.02.001 · Cited by 124
Meltzer, E. O. (2000) · Annals of Allergy, Asthma & Immunology · doi:10.1016/s1081-1206(10)62750-0 · Cited by 67
Metadata
- Authors
- BISGAARD, H., OLSSON, P., & BENDE, M.
- Venue
- Clinical & Experimental Allergy
- Publisher
- Wiley
- Published
- 1986-07
- Volume
- 16
- Issue
- 4
- Pages
- 289-297
- ISSN
- 0954-7894 (ISSN-L)
- 1365-2222
- OpenAlex
- W1978837864
- Cited by
- 167
- References
- 0
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effect of leukotriene D4 on nasal mucosal blood flow, nasal airway resistance and nasal secretion in humans. https://app.cochat.ai/papers/10.1111/j.1365-2222.1986.tb01960.x
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- BISGAARD, H., OLSSON, P., & BENDE, M. (1986). Effect of leukotriene D4 on nasal mucosal blood flow, nasal airway resistance and nasal secretion in humans. Clinical & Experimental Allergy. https://doi.org/10.1111/j.1365-2222.1986.tb01960.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
