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Cited by 38Infectious Diseases and TuberculosisHIV-related health complications and treatmentsDrug-Induced Adverse Reactions

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Immune reconstitution inflammatory syndrome involving the skin

Osei-Sekyere, B., Karstaedt, A. S.·2009·Clinical and Experimental Dermatology
DOI 10.1111/j.1365-2230.2009.03620.x
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Abstract

BACKGROUND: Immune reconstitution inflammatory syndrome (IRIS) occurs in 10-25% of unselected patients starting highly active antiretroviral therapy (HAART). About 52-78% of these cases involve cutaneous features. AIM: To describe the prevalence and incidence of new dermatological conditions within 6 months of patients starting HAART, and to specify the clinical and immunological features and time of onset in patients responding to HAART. METHODS: A retrospective cohort analysis was performed of 59 treatment-naive patients started on HAART and followed up for 6 months by a clinician trained in dermatology. Medical records were reviewed for new dermatological conditions diagnosed clinically. RESULTS: In all, 30 patients (50.8%) developed 45 new skin conditions at a median of 8 weeks (range 3-24 weeks) after starting HAART. The incidence rate was 104.5 cases per 100 patient-years. Diagnoses included seborrhoeic dermatitis (nine patients), anogenital herpes (seven patients), acne, tinea and folliculitis (six patients each), Kaposi's sarcoma, herpes zoster, genital warts and eczema (two patients each), and molluscum contagiosum, planar warts and pityriasis versicolor (one patient each). Significantly more women (23/38; 60.5%) than men (7/21; 33.3%) (P < 0.05) developed new skin lesions after starting HAART. Baseline median CD4 counts in those with and without IRIS were 60/microL and 62/microL, respectively, and in both groups, the counts increased to > 90/microL by week 12. Baseline median viral load was > 100,000 copies/mL and was < or = 32 copies/mL by week 12. In both groups, the majority of patients were in World Health Organization stages 3 and 4. CONCLUSIONS: New skin lesions were very common in this cohort, with the majority being women and patients with very low baseline CD4 counts.

Overview

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Crossref · 10.1111/j.1365-2230.2009.03620.x

Cites

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Metadata

Authors
Osei-Sekyere, B., & Karstaedt, A. S.
Affiliations
University of the Witwatersrand (ZA)
Corresponding author
Karstaedt, A. S.
Venue
Clinical and Experimental Dermatology
Publisher
Oxford University Press (OUP)
Published
2009-10-23
Volume
35
Issue
5
Pages
477-481
ISSN
  • 0307-6938 (ISSN-L)
  • 1365-2230
DOI
10.1111/j.1365-2230.2009.03620.x
OpenAlex
W1950063952
Cited by
38
References
23
Citations by year
2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 3
FWCI
2.35
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2139 d)
Locations
  • Clinical and Experimental Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
  • Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
  • Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
Keywords
immune reconstitution inflammatory syndrome, cutaneous manifestations, highly active antiretroviral therapy, HIV infection, seborrheic dermatitis, anogenital herpes, Kaposi's sarcoma, herpes zoster, genital warts, CD4 count, viral load, sex differences, incidence
MeSH terms
Adult, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Skin Diseases, South Africa, Time Factors, Cohort Studies, HIV Infections, CD4 Lymphocyte Count, Antiretroviral Therapy, Highly Active, Immune Reconstitution Inflammatory Syndrome, Young Adult

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.