The DOI matches its Crossref record.
Percutaneous collagen induction. Scarless skin rejuvenation: fact or fiction?
Abstract
Summary: Photoageing is generally treated by ablative procedures that injure the epidermis and basement membrane, and lead to fibrosis of the dermis. Percutaneous collagen induction (PCI) therapy is an alternative treatment for photoaged skin that does not result in clinical signs of dermal fibrosis. In this study, the immediate effects of PCI on the skin were assessed, including the systemic inflammatory response and the production and gene expression of transforming growth factor (TGF) isoforms β1, β2 and β3. Eighty rats were split into four groups: group 1 (n = 24; PCI plus skin care); group 2 (n = 24; skin care only); group 3 (n = 24; PCI only) and group 4 (n = 8; controls). Microarray analysis showed that TGF-β3, an essential marker for preventing scarring, was upregulated and expressed for 2 weeks postoperatively. PCI might offer a regenerative therapy to improve skin appearance and quality and to improve or even prevent scarring.
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After microneedling, TGF-beta3 is upregulated, followed by downregulation of TGF-beta1 and TGF-beta2.
“Studies have also shown that TGF-beta3, a key marker for preventing scarring, is upregulated after microneedling, followed by a downregulation of TGF-beta1 and TGF-beta2.21”
Microneedling creates micro-injuries that stimulate the release of growth factors such as platelet-derived growth factor, epidermal growth factor (EGF), fibroblast growth factor (FGF), and transforming growth factors (TGF-alpha and TGF-beta).
“Microneedling creates micro-injuries that stimulate the release of growth factors such as platelet-derived growth factor, epidermal growth factor (EGF), fibroblast growth factor (FGF), and transforming growth factors (TGF-alpha and TGF-beta).”
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Research works printed but not linked: 8
- Fulton, 2004, Chemical peels: their place within the range of resurfacing techniques, Am J Clin Dermatol, 5, 179, 10.2165/00128071-200405030-00006 · DOI
- Dover, 1996, Laser skin resurfacing, Semin Cutan Med Surg, 15, 177, 10.1016/S1085-5629(96)80009-5 · DOI
- Ferguson, 2004, Scar-free healing: from embryonic mechanisms to adult therapeutic intervention, Philos Trans R Soc Lond B Biol Sci, 359, 839, 10.1098/rstb.2004.1475 · DOI · Paper page
- Aust, 2008, Collagen induction therapy (PCI) – an alternative treatment for scars, wrinkles and skin laxity, Plast Reconstr Surg, 121, 1421, 10.1097/01.prs.0000304612.72899.02 · DOI
- Aust, 2008, Percutaneous collagen induction (PCI) – minimally invasive skin rejuvenation without risk of hyperpigmentation – fact or fiction?, Plast Reconstr Surg, 122, 1553, 10.1097/PRS.0b013e318188245e · DOI · Paper page
- Bayat, 2003, Skin scarring, BMJ, 326, 88, 10.1136/bmj.326.7380.88 · DOI · Paper page
- Brazma, 2001, Minimum information about a microarray experiment (MIAME) – toward standards for microarray data, Nat Genet, 29, 365, 10.1038/ng1201-365 · DOI · Paper page
- Fernandes, 2002, Percutanous collagen induction: an alternative to laser resurfacing, Aesthet Surg J, 22, 315, 10.1067/maj.2002.126195 · DOI
Cited by
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Liu, C., Boo, J., Kim, H., Hwang, S., Yan, X., Brieva, P., Kim, J., & Kim, J. (2026) · Clinical, Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s565035 · Cited by 1
“21 This initiates fibroblast proliferation and migration, followed by the formation of a fibronectin matrix.”
Metadata
- Authors
- Aust, M. C., Reimers, K., Gohritz, A., Jahn, S., Stahl, F., Repenning, C., Scheper, T., Altintas, M. A., Schwaiger, N., Redeker, J., & Vogt, P. M.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Leibniz University Hannover (DE)
- Clinical Department of Hand and Plastic Surgery, Friederikenstift Hannover, Hannover, Germany
- Corresponding author
- Aust, M. C.
- Venue
- Clinical and Experimental Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-06-01
- Volume
- 35
- Issue
- 4
- Pages
- 437-439
- ISSN
- 0307-6938 (ISSN-L)
- 1365-2230
- OpenAlex
- W2110644251
- Cited by
- 66
- References
- 0
- Citations by year
- 2026: 3 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 3 · 2019: 9 · 2018: 7 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical and Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- photoaging, skin fibrosis, TGF-beta3, TGF-β1, TGF-beta2, systemic inflammatory response, skin gene expression, regenerative therapy, skin care
- MeSH terms
- Animals, Cicatrix, Collagen, Gene Expression Regulation, Male, Needles, Physical Stimulation, Rejuvenation, Skin, Skin Aging, Transforming Growth Factor beta, Rats, Sprague-Dawley, Rats
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