The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn's disease
Open accessAbstract
SUMMARY: IL-8 is generating increasing interest as a powerful neutrophil chemoattractant and activator. To elucidate the mechanisms of neutrophil infiltration in inflammatory bowel disease, we examined 33 patients with ulcerative colitis (UC),18 with Crohn's disease (CD), eight with some other type of colitis, and 18 normal control subjects for measurement of IL-8 in homogenates of colonic biopsy specimens. The affected colonic mucosa was found lo contain significantly more IL-8 in patients with active inflammatory bowel disease than in patients with inactive disease (UC, P<0.001: CD, P<0.001), in patients with other types of colitis (UC, P<0.05; CD, P<0.01), or in normal control subjects (UC. P<0.001; CD. P<0.001). Colonic IL-8 levels correlated significantly with the macroscopic grade of local inflammation, especially in patients with UC (P< 0.001). Colonic lL-8 levels also correlated well with the neutrophil numbers in mucosal tissue (UC, r = 0.950, P<0.001; CD. r=0-940, P<0.001), and with colonic IL-1β (r=0.911, P<0.001) and tumour necrosis factor-alpha (TNF-a) levels (r=0-604. P < 0001) in patients with these two conditions. These data suggest a potential role for IL-8 and its regulatory cytokines IL-I and TNF-a in mediating neutrophil infiltration of the gut wall in inflammatory bowel disease.
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Carré, P. C., Mortenson, R. L., King, T. E., Noble, P. W., Sable, C. L., & Riches, D. W. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115501 · Cited by 253
Chemotactic activity in inflammatory bowel disease: Role of leukotriene B4
Lobos, E. A., Sharon, P., & Stenson, W. F. (1987) · Digestive Diseases and Sciences · doi:10.1007/bf01296664 · Cited by 143
Macrophage activation, chronic inflammation and gastrointestinal disease
Tanner, A. R., Arthur, M. J., & Wright, R. (1984) · Gut · doi:10.1136/gut.25.7.760 · Cited by 70
Cited by
Mucosal Prevalence and Interactions with the Epithelium Indicate Commensalism of Sutterella spp.
Hiippala, K., Kainulainen, V., Kalliomäki, M., Arkkila, P., & Satokari, R. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01706 · Cited by 351
“…isolates from patients and healthy individuals are needed to confirm our findings on the commensal nature of Sutterella spp. IECs secrete a cytokine IL-8 in response to various inflammatory stimuli activating neutrophils into the infected mucosa (Lammers et al., 1994; Mitsuyama et al., 1994).”
BackgroundBanks, C., Bateman, A., Payne, R., Johnson, P., & Sheron, N. (2003) · The Journal of Pathology · doi:10.1002/path.1245 · Cited by 344
The Key Role of Macrophages in the Immunopathogenesis of Inflammatory Bowel Disease
Mahida, Y. R. (2000) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200002000-00004 · Cited by 293
Metadata
- Authors
- MITSUYAMA, K., TOYONAGA, A., SASAKI, E., WATANABE, K., TATEISHI, H., NISHIYAMA, T., SAIKI, T., IKEDA, H., TSURUTA, O., & TANIKAWA, K.
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-06
- Volume
- 96
- Issue
- 3
- Pages
- 432-436
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- OpenAlex
- W1994099910
- Cited by
- 236
- References
- 3
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn's disease. https://app.cochat.ai/papers/10.1111/j.1365-2249.1994.tb06047.x
- The paper
- MITSUYAMA, K., TOYONAGA, A., SASAKI, E., WATANABE, K., TATEISHI, H., NISHIYAMA, T., SAIKI, T., IKEDA, H., TSURUTA, O., & TANIKAWA, K. (2008). IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn's disease. Clinical and Experimental Immunology. https://doi.org/10.1111/j.1365-2249.1994.tb06047.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
