The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Proportion of peripheral blood and decidual CD4+ CD25bright regulatory T cells in pre-eclampsia
Open accessAbstract
Summary: CD4+ CD25bright regulatory T (Treg) cells have been identified as a principle regulator of tolerance during pregnancy. In the setting of pre-eclampsia, however, little is known about the dynamics of these cells. In the current study, we determined CD4+ CD25bright Treg cells in the peripheral blood using flow cytometry and forkhead box P3 (FoxP3+) cells at the placental bed using immunohistochemical staining. Peripheral blood mononuclear cells (PBMC) of 38 pre-eclamptic cases (17 cases Japanese, 21 cases Polish), 40 normal late pregnancy subjects (20 subjects Japanese, 20 subjects Polish), and 21 non-pregnant healthy controls (10 subjects Japanese, 11 subjects Polish) were included. We found the percentage of CD25bright cells within the CD4+ T cell population in PBMC was reduced significantly in both Japanese and Polish pre-eclamptic cases than in normal pregnancy subjects (P < 0·001) and non-pregnant healthy controls (P < 0·001). Also, the percentage of FoxP3+ cells within CD3+ T cells in the placental bed biopsy samples of pre-eclamptic cases were decreased compared to those in normal pregnancy subjects. These findings suggest that a decreased number of Treg cells was present in pre-eclampsia, and these changes might break the maternal tolerance to the fetus.
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Citations
Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Cited by
The role of the immune system in preeclampsia
Saito, S., Shiozaki, A., Nakashima, A., Sakai, M., & Sasaki, Y. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.02.006 · Cited by 351
Self-citationThe T helper type 17/regulatory T cell paradigm in pregnancy
Figueiredo, A. S., & Schumacher, A. (2016) · Immunology · doi:10.1111/imm.12595 · Cited by 283
Comparison of clustering tools in R for medium-sized 10x Genomics single-cell RNA-sequencing data
Freytag, S., Tian, L., Lönnstedt, I., Ng, M., & Bahlo, M. (2018) · F1000Research · doi:10.12688/f1000research.15809.1 · Cited by 220
Gao, L., Mathur, V., Tam, S. K. M., Zhou, X., Cheung, M. F., Chan, L. Y., Estrada-Gutiérrez, G., Leung, B. W., Moungmaithong, S., Wang, C. C., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01169-x · Cited by 31
Metadata
- Authors
- Sasaki, Y., Darmochwal-Kolarz, D., Suzuki, D., Sakai, M., Ito, M., Shima, T., Shiozaki, A., Rolinski, J., & Saito, S.
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04-25
- Volume
- 149
- Issue
- 1
- Pages
- 139-145
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- OpenAlex
- W1695756438
- Cited by
- 352
- References
- 1
- FWCI
- 16.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Sasaki, Y., Darmochwal-Kolarz, D., Suzuki, D., Sakai, M., Ito, M., Shima, T., Shiozaki, A., Rolinski, J., & Saito, S. (2007). Proportion of peripheral blood and decidual CD4+ CD25bright regulatory T cells in pre-eclampsia. Clinical and Experimental Immunology. https://doi.org/10.1111/j.1365-2249.2007.03397.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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