The Effect of Growth Hormone on the Leydig Cell Response to Chorionic Gonadotrophin in Boys With Hypopituitarism
Abstract
Eleven boys with growth hormone (hGH) deficiency received human chorionic gonadotrophin (hCG) stimulation tests for the assessment of Leydig cell function before, during, and after 1 year of treatment with somatotrophin. Two patients entered puberty during the course of the study protocol. Analysis of the data in nine prepubertal boys revealed an augmentation of testosterone (T) responses to hCG in the presence of hGH. In six of these individuals in whom dihydrotestosterone (DHT) was determined, a similar augmentation in responsiveness of this steroid was found in the presence of hGH. Three prepubertal boys exhibited poor T responses to the basal hCG test with only partial improvement following hGH. In man growth hormone may be an important permissive factor in Leydig cell activity during periods of changing testicular function such as occur in utero or during puberty.
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rhGH therapy increases HCG-induced testosterone secretion in hypopituitary boys and adults.
“Previous studies demonstrated that rhGH therapy increased HCG-induced testosterone secretion in hypopituitary boys (25, 26) and adults (7).”
From Growth Hormone Is Beneficial for Induction of Spermatogenesis in Adult Patients With Congenital Combined Pituitary Hormone Deficiency (2022) · cites this paper as [25]
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References 19 · Cited by 65
- Authors
- KULIN, H. E., SAMOJLIK, E., SANTEN, R., & SANTNER, S.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- KULIN, H. E.
- ORCID
- SANTEN, R.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 1981-11
- Volume
- 15
- Issue
- 5
- Pages
- 463-472
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2149485072
- Cited by
- 65
- References
- 19
- Citations by year
- 2022: 1 · 2021: 1 · 2019: 1 · 2017: 1
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- March of Dimes Foundation
- Santen
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- growth hormone deficiency, hypopituitarism, Leydig cell function, human chorionic gonadotropin stimulation test, testosterone response, dihydrotestosterone, growth hormone, puberty, prepubertal boys, testicular steroidogenesis
- MeSH terms
- Adolescent, Androstenedione, Child, Child, Preschool, Chorionic Gonadotropin, Humans, Hypopituitarism, Leydig Cells, Male, Puberty, Growth Hormone, Dihydrotestosterone, Testosterone
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