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The relationship between hCG and relaxin secretion in normal pregnancies vs peri‐implantation spontaneous abortions1

Stewart, Dennis R., Overstreet, James W., Celniker, Abbie C., Hess, David L., Cragun, Jeffry R., Boyers, Stephen P., Lasley, Bill L.·1993·Clinical Endocrinology
DOI 10.1111/j.1365-2265.1993.tb00518.x
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Abstract

Summary: OBJECTIVE We determined the ovarian response to human chorionic gonadotrophin (hCG) in terms of relaxin and progesterone secretion during the peri‐implantation period of normal and failing pregnancies. We wished to test the hypotheses that relaxin production in failing pregnancies is different from that in normal pregnancies, that relaxin is a reliable, quantitative indicator of the biological activity of endogenous hCG, and that relaxin is a useful predictor of peri‐implantation spontaneous abortions. DESIGN Daily blood samples were collected in a prospective longitudinal study from insemination patients. PATIENTS Women undergoing artificial insemination in natural cycles with non‐frozen donor semen at a University clinic. MEASUREMENTS Serum LH, hCG, relaxin and progesterone were measured and the relationship between hCG and the ovarian hormones was evaluated in the peri‐implantation period of normal pregnancies and spontaneous abortions. RESULTS Nine of 23 conceptive cycles resulted in a spontaneous abortion between 16 and 70 days after the LH peak. In all normal and failing pregnancies there was a close qualitative relationship between hCG secretion and relaxin production. Six of nine failing pregnancies were associated with abnormally low hCG secretion. Six of the spontaneous abortions were associated with rates of relaxin secretion which were higher than the mean of 14 normal pregnancies. No such alterations in progesterone concentrations were observed. In cases where hCG was extremely low, the quantitative relationship between hCG and relaxin was different from that in cases of normal hCG concentrations. CONCLUSIONS There is a close temporal relationship between the secretion of trophoblastic hCG and ovarian secretion of relaxin in the peri‐implantation period of normal and failing pregnancies. In failing pregnancies there is substantial variability in the quantitative relationship between relaxin and hCG, indicating that relaxin is not a reliable quantitative indicator of hCG bioactivity. Contrary to previous reports, relaxin concentrations in failing pregnancies tended to be higher than or equal to concentrations in normal pregnancies until the loss was imminent. Because of this relaxin is not a useful predictor of peri‐implantation spontaneous abortions.

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Crossref · 10.1111/j.1365-2265.1993.tb00518.x

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  • In a study of 14 pregnancies ending in live births, rises in serum chorionic gonadotropin were detected as early as 8 days and as late as 12 days after the peak serum concentration of luteinizing hormone.

    “In a study of 14 pregnancies ending in live births, rises in serum chorionic gonadotropin were detected as early as 8 days and as late as 12 days after the peak serum concentration of luteinizing hormone.26”

    From Time of Implantation of the Conceptus and Loss of Pregnancy (1999) · cites this paper as [26]

  • The only previous study of the timing of implantation in women with no known fertility problems reported results similar to ours.

    “The only previous study of the timing of implantation in women with no known fertility problems reported results similar to ours.”

    From Time of Implantation of the Conceptus and Loss of Pregnancy (1999) · cites this paper as [26]

Citations

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No references could be resolved yet.

Research works printed but not linked: 24

  1. Bell R.J., 1987, Relaxin in human pregnancy serum measured with a homologous radioimmunoassay, Obstetrics and Gynecology, 69, 585
  2. Bell R.J., 1989, Relaxin levels in antenatal patients following in vitro fertilization, Fertility and Sterility, 52, 85, 10.1016/S0015-0282(16)60794-X · DOI
  3. 10.1210/jcem-69-5-956 · DOI
  4. 10.1016/0140-6736(90)91765-3 · DOI
  5. 10.1095/biolreprod22.4.955 · DOI
  6. 10.1210/jcem-72-6-1359 · DOI
  7. Garcia A., 1990, Human chorionic gonadotropin and relaxin concentrations in early ectopic and normal pregnancies, Obstetrics and Gynecology, 75, 779
  8. Haning R.V., 1985, Elevated serum relaxin levels in multiple pregnancy after menotropin treatment, Obstetrics and Gynecology, 66, 42
  9. 10.1016/S0015-0282(16)54416-1 · DOI
  10. 10.1210/jcem-72-5-1042 · DOI
  11. 10.1016/S0015-0282(16)48613-9 · DOI
  12. Lenton E., 1985, Clinical Reproductive Endocrinology, 81
  13. 10.1677/joe.0.1200449 · DOI
  14. 10.1016/S0015-0282(16)45745-6 · DOI
  15. 10.1210/jcem-68-2-379 · DOI
  16. 10.1159/000293775 · DOI
  17. Sherwood O., 1988, The Physiology of Reproduction, 585
  18. 10.1210/jcem-70-6-1771 · DOI
  19. Stewart D.R., 1992, Serum relaxin concentrations in patients with out‐of‐phase endometrial biopsies, Fertility and Sterility, 57, 453, 10.1016/S0015-0282(16)54865-1 · DOI
  20. Szlachter B.N., 1982, Relaxin in normal and pathogenic pregnancies, Obstetrics and Gynecology, 59, 167
  21. Taylor C., 1992, Prospective assessment of early fetal loss using an ezyme immunoradiometric screening assay for detection of urinary human chorionic gonadotropin, Fertility and Sterility, 51, 1220, 10.1016/S0015-0282(16)55077-8 · DOI
  22. 10.1126/science.982052 · DOI
  23. 10.1056/NEJM198807283190401 · DOI · Paper page
  24. 10.1016/S0015-0282(16)53580-8 · DOI

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Metadata

Authors
Stewart, D. R., Overstreet, J. W., Celniker, A. C., Hess, D. L., Cragun, J. R., Boyers, S. P., & Lasley, B. L.
Venue
Clinical Endocrinology
Publisher
Wiley
Published
1993-04
Volume
38
Issue
4
Pages
379-385
ISSN
  • 0300-0664
  • 1365-2265
DOI
10.1111/j.1365-2265.1993.tb00518.x
Cited by
49
References
0
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5464 d)

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