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The sick euthyroid syndrome: changes in thyroid hormone serum parameters and hormone metabolism
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“While serum T3 levels may decline by 30%, which is significant, but still within the so-called “normal range”, tissue T3 may decline by 70–80%, resulting in profound cellular hypothyroidism with normal serum TSH, FT4, and FT3 levels”
From Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report (2017) · cites this paper as [31]
In the citing paper
“As a result, TSH may be a poor indicator of peripheral thyroid levels in the presence of such conditions.”
From Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report (2017) · cites this paper as [31]
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Metadata
- Authors
- Docter, R., Krenning, E. P., de Jong, M., & Hennemann, G.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Docter, R.
- ORCID
- Krenning, E. P.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 1993-11
- Volume
- 39
- Issue
- 5
- Pages
- 499-518
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2121588417
- Cited by
- 345
- References
- 242
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 12 · 2021: 6 · 2020: 8 · 2019: 12 · 2018: 6 · 2017: 6 · 2016: 10 · 2015: 10 · 2014: 9 · 2013: 12 · 2012: 10
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- low T3 syndrome, thyroid hormones, serum thyroid hormones, thyroid hormone metabolism
- MeSH terms
- Euthyroid Sick Syndromes, Humans, Thyroid Hormones, Thyrotropin, Thyroxine, Triiodothyronine
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