The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Medullary thyroid carcinoma
Abstract
Summary: Medullary thyroid carcinoma (MTC) arises from parafollicular or C cells that produce calcitonin (CT), and accounts for 5–10% of all thyroid cancers. MTC is hereditary in about 25% of cases. The discovery of a MTC in a patient has several implications: disease extent should be evaluated, phaeochromocytoma and hyperparathyroidism should be screened for and whether the MTC is sporadic or hereditary should be determined by a direct analysis of the RET proto‐oncogene. In this review, pathological characteristics, tumour markers and genetic abnormalities in MTC are discussed. The diagnostic and therapeutic modalities applied to patients with clinical MTC and those identified with preclinical disease through familial screening are also described. Progresses concerning genetics, initial treatment, follow‐up, screening and treatment of pheochromocytoma have permitted an improvement in the long‐term outcome. However, there is no effective treatment for distant metastases, and new therapeutic modalities are urgently needed.
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Cites
CONSENSUS: Guidelines for Diagnosis and Therapy of MEN Type 1 and Type 2
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Hofstra, R. M. W., Landsvater, R. M., Ceccherini, I., Stulp, R. P., Stelwagen, T., Luo, Y., Pasini, B., Hoppener, J. W. M., van Amstel, H. K. P., Romeo, G., et al. (1994) · Nature · doi:10.1038/367375a0 · Cited by 1,149
Biochemical Diagnosis of Pheochromocytoma: Which Test Is Best?
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Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B
Santoro, M., Carlomagno, F., Romano, A., Bottaro, D. P., Dathan, N. A., Grieco, M., Fusco, A., Vecchio, G., Matoskova, B., Kraus, M. H., et al. (1995) · Science · doi:10.1126/science.7824936 · Cited by 841
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Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC
Mulligan, L. M., Eng, C., Healey, C. S., Clayton, D., Kwok, J. B. J., Gardner, E., Ponder, M. A., Frilling, A., Jackson, C. E., Lehnert, H., et al. (1994) · Nature Genetics · doi:10.1038/ng0194-70 · Cited by 652
Histological Typing of Thyroid Tumours
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Self-citationEarly Malignant Progression of Hereditary Medullary Thyroid Cancer
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Cited by
Schlumberger, M. J., Elisei, R., Bastholt, L., Wirth, L. J., Martins, R. G., Locati, L. D., Jarzab, B., Pacini, F., Daumerie, C., Droz, J.-P., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.7815 · Cited by 340
Self-citationHegedüs, L., Moses, A. C., Zdravkovic, M., Le Thi, T., & Daniels, G. H. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2318 · Cited by 194
Calcitonin as a biomarker of C cell disease: recent achievements and current challenges
Costante, G., & Meringolo, D. (2020) · Endocrine · doi:10.1007/s12020-019-02183-6 · Cited by 41
Metadata
- Authors
- Leboulleux, S., Baudin, E., Travagli, J., & Schlumberger, M.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2004-05-18
- Volume
- 61
- Issue
- 3
- Pages
- 299-310
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W3023775406
- Cited by
- 281
- References
- 30
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Leboulleux, S., Baudin, E., Travagli, J., & Schlumberger, M. (2004). Medullary thyroid carcinoma. Clinical Endocrinology. https://doi.org/10.1111/j.1365-2265.2004.02037.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
