Cited by 167Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and related disorders

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Phase‐shifts of 24‐h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men

Leproult, Rachel, Van Onderbergen, Anne, L’Hermite‐Balériaux, Mireille, Van Cauter, Eve, Copinschi, Georges·2005·Clinical Endocrinology

DOI 10.1111/j.1365-2265.2005.02341.x

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Abstract

Summary: Objective Older adults are less responsive to the phase‐shifting effects of light than younger subjects and may have difficulties adapting to abrupt time shifts. This study aims to determine whether the potent melatonin agonist agomelatine (S‐20098) is capable of phase‐shifting overt circadian rhythms in older adults. Subjects and design Eight healthy elderly men participated in a double‐blind, two‐period, cross‐over study of 15 days of daily administration of either agomelatine (50 mg) or placebo at 1830 h. Measurements At the end of each treatment period, the 24‐h profiles of body temperature and of the plasma levels of GH, PRL, cortisol and TSH were collected and sleep was monitored polygraphically. Results Phase‐advances, averaging nearly 2 h, were observed for the temperature profile and for the variables characterizing the temporal organization of cortisol secretion following agomelatine administration. A similar trend was observed for the circadian rise of plasma TSH. There was no effect of agomelatine on any of the sleep variables. Agomelatine stimulated GH secretion during the wake period and was associated with a transient elevation of PRL levels. Conclusions Melatonin agonists such as agomelatine may be useful to phase‐shift at least some overt circadian rhythms in older adults.

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Authors: Leproult, R., Van Onderbergen, A., L’Hermite‐Balériaux, M., Van Cauter, E., & Copinschi, G.
Affiliations: Université Libre de Bruxelles (BE)
Corresponding author: Leproult, Rachel
ORCID: Leproult, Rachel
Copinschi, Georges
Venue: Clinical Endocrinology
Publisher: Wiley
Published: 2005-08-02
Volume: 63
Issue: 3
Pages: 298-304
ISSN: 0300-0664 (ISSN-L)
1365-2265
DOI: 10.1111/j.1365-2265.2005.02341.x
OpenAlex: W2080424914
Cited by: 167
References: 50
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 6 · 2013: 16 · 2012: 7
FWCI: 4.66
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Clinical Endocrinology (publishedVersion)
PubMed (publishedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Funders: National Institutes of Health
National Institute on Aging (P01AG011412, AG-11412)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords: agomelatine, melatonin receptor agonists, circadian phase shifting, older adults, body temperature rhythm, cortisol secretion, growth hormone, prolactin, thyroid-stimulating hormone, sleep, chronobiology
MeSH terms: Acetamides, Aged, Body Temperature, Circadian Rhythm, Double-Blind Method, Hormones, Humans, Hydrocortisone, Male, Melatonin, Middle Aged, Monitoring, Physiologic, Naphthalenes, Prolactin, Sleep, Growth Hormone, Stimulation, Chemical, Thyrotropin, Cross-Over Studies, Jet Lag Syndrome

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Phase‐shifts of 24‐h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men

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