Leptin, adiponectin and other adipokines in gestational diabetes mellitus and pre‐eclampsia
Abstract
Proteins secreted from adipocytes - so-called adipokines - influence metabolic and vascular function. Recent data suggest that various adipokines are dysregulated in gestational diabetes mellitus (GDM) and pre-eclampsia (PE) and might be of pathophysiological and prognostic significance in these complications of pregnancy. This review gives an overview on the regulation and pathophysiology of leptin and adiponectin in GDM and PE. Furthermore, data on novel adipokines including resistin, visfatin, retinol-binding protein 4 and vaspin are summarized.
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In women with gestational diabetes, adiponectin concentration is lower than in pregnant women without disturbances of carbohydrate metabolism, regardless of pre-pregnancy BMI.
“In women with gestational diabetes, the concentration of adiponectin is lower than in pregnant women without disturbances of carbohydrate metabolism, regardless of their pre-pregnancy BMI [49].”
From Gestational Diabetes Mellitus—Recent Literature Review (2022) · cites this paper as [49]
Cites
1 retracted
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Gestational Diabetes Mellitus—Recent Literature Review
Modzelewski, R., Stefanowicz-Rutkowska, M. M., Matuszewski, W., & Bandurska-Stankiewicz, E. M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11195736 · Cited by 223 · see citing works
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- Authors
- Miehle, K., Stepan, H., & Fasshauer, M.
- Affiliations
- Leipzig University (DE)
- IFB Adiposity Diseases (DE)
- Corresponding author
- Fasshauer, Mathias
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2011-12-07
- Volume
- 76
- Issue
- 1
- Pages
- 2-11
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W1960632165
- Cited by
- 236
- References
- 6
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 22 · 2021: 11 · 2020: 18 · 2019: 22 · 2018: 17 · 2017: 22 · 2016: 20 · 2015: 21 · 2014: 21 · 2013: 18 · 2012: 7
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Deutsche Hochdruckliga
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- leptin, adiponectin, adipokines, gestational diabetes mellitus, preeclampsia, resistin, visfatin, retinol-binding protein 4, vaspin, pregnancy complications, pathophysiology, prognostic factors
- MeSH terms
- Female, Humans, Pre-Eclampsia, Pregnancy, Diabetes, Gestational, Leptin, Adiponectin
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