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HAb18G (CD147), a cancer‐associated biomarker and its role in cancer detection
Abstract
Aims: To evaluate HAb18G/CD147 as a cancer‐associated biomarker using its monoclonal antibody HAb18. Methods and results: On immunohistochemical analysis of 28 tissue microarrays and pathological sections of 1117 breast tissue samples, HAb18G/CD147 was expressed in carcinoma with an overall positivity rate of 67.76%, which was significantly higher than that in sarcomas (27.34%, P < 0.0001) and normal epithelial (5.18%, P < 0.0001) and fetal (2.67%, P < 0.0001) tissues. In epithelial tissues from 14 organs, the difference in HAb18G/CD147 expression between normal epithelium and the corresponding carcinoma was also significant (P < 0.05 for each pair). This expression in carcinoma was also found at the mRNA level, suggesting transcriptional level regulation of HAb18G/CD147 expression. In a retrospective study of 106 patients with infiltrating ductal carcinoma of the breast, the level of HAb18G/CD147 expression was positively correlated with tumour recurrence/metastasis (P = 0.0003) and negatively correlated with survival of breast cancer patients (P = 0.002). Multivariable Cox regression analysis showed that HAb18G/CD147 was an independent prognostic factor. Conclusions: HAb18G/CD147 is significantly expressed in various cancers and appears to have prognostic significance, rendering it a possible cancer‐associated biomarker for pathological diagnosis, prognostic evaluation, targeted therapy and radioimmunoimaging of a broad range of cancer types.
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Cited by
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters
Marchiq, I., & Pouysségur, J. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1307-x · Cited by 300
Metadata
- Authors
- Li, Y., Xu, J., Chen, L., Zhong, W., Zhang, Z., Mi, L., Zhang, Y., Liao, C., Bian, H., Jiang, J., Yang, X., Li, X., Fan, C., Zhu, P., Fu, L., & Chen, Z.
- Venue
- Histopathology
- Publisher
- Wiley
- Published
- 2009-04-24
- Volume
- 54
- Issue
- 6
- Pages
- 677-687
- ISSN
- 0309-0167 (ISSN-L)
- 1365-2559
- OpenAlex
- W1975310898
- Cited by
- 174
- References
- 0
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, Y., Xu, J., Chen, L., Zhong, W., Zhang, Z., Mi, L., Zhang, Y., Liao, C., Bian, H., Jiang, J., Yang, X., Li, X., Fan, C., Zhu, P., Fu, L., & Chen, Z. (2009). HAb18G (CD147), a cancer‐associated biomarker and its role in cancer detection. Histopathology. https://doi.org/10.1111/j.1365-2559.2009.03280.x
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