Aneuploidy and DNA fragmentation in morphologically abnormal sperm
Open accessAbstract
In light of the relative success of ICSI in the treatment of male infertility, much importance has been made to the selection of morphologically viable sperm. However, correlation between specific sperm morphology and chromosomal abnormalities is still relatively limited and less is known about the connection between sperm morphology and DNA integrity. Sperm obtained from isolated teratozoospermic men (n = 10) and control men (n = 9) were analysed using FISH (for chromosomes 13, 18, 21, X and Y) and TUNEL assays to determine the level of aneuploidy and DNA fragmentation. Sperm morphology was evaluated on its ability to identify the level of chromosomal abnormalities or fragmented DNA in sperm. Sperm from teratozoospermic men, compared with fertile men, had higher rates of total chromosomal abnormality (p < 0.05), total aneuploidy (p < 0.01) and chromosome 13 disomy (p < 0.01). Associations between particular types of sperm morphology and chromosomal abnormalities were observed in both control (tapered heads) and teratozoospermic (amorphous heads and tail abnormalities) samples. Levels of DNA fragmented sperm were higher in teratozoospermic men than in the control men (60.28 +/- 21.40% vs. 32.40 +/- 17.20%, p < 0.05) and positively correlated to sperm with bent necks in control samples and round heads in teratozoospermic samples (p < 0.05). Sperm of isolated teratozoospermic men have higher rates of chromosomal abnormalities and DNA fragmentation than that of the fertile contr…
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Men with isolated teratozoospermia have higher rates of sperm DNA fragmentation, chromosomal aneuploidy, and chromosome 13 disomy.
“Men with isolated teratozoospermia have higher rates of SDF, chromosomal aneuploidy, and chromosome 13 disomy.”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [73]
These factors are primarily associated with aberrant sperm with round heads, amorphous heads, and tail defects.
“These factors are primarily associated with aberrant sperm with round heads, amorphous heads, and tail defects (73).”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [73]
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Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review
Atmoko, W., Savira, M., Shah, R., Chung, E., & Agarwal, A. (2024) · Translational Andrology and Urology · doi:10.21037/tau-23-397 · Cited by 23 · see citing works
“These factors are primarily associated with aberrant sperm with round heads, amorphous heads, and tail defects (73).”
- Authors
- Tang, S. S., Gao, H., Zhao, Y., & Ma, S.
- Affiliations
- University of British Columbia (CA)
- Johns Hopkins University (US)
- Corresponding author
- Ma, S.
- Venue
- International Journal of Andrology
- Publisher
- Wiley
- Published
- 2010-01-08
- Volume
- 33
- Issue
- 1
- Pages
- e163-79
- ISSN
- 0105-6263 (ISSN-L)
- 1365-2605
- OpenAlex
- W1956277467
- Cited by
- 78
- References
- 0
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 8 · 2014: 5 · 2013: 9 · 2012: 5
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- International Journal of Andrology (publishedVersion)
- PubMed (publishedVersion)
- cIRcle (University of British Columbia) (submittedVersion, cc-by-nc-nd)
- Open Collections
- Funders
- Canadian Institutes of Health Research (BMH86005, MOP53067)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Keywords
- sperm morphology, aneuploidy, sperm DNA fragmentation, teratozoospermia, male infertility, sperm selection, intracytoplasmic sperm injection, sperm head abnormalities
- MeSH terms
- Aneuploidy, Chromosome Aberrations, Chromosomes, Human, Pair 13, Humans, Infertility, Male, Male, Spermatozoa, Sperm Injections, Intracytoplasmic, DNA Fragmentation, Semen Analysis
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