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Classification and Antihypertensive Activity of Angiotensin I‐Converting Enzyme Inhibitory Peptides Derived from Food Proteins
Abstract
ABSTRACT: Angiotensin I‐converting enzyme (ACE)‐inhibitory peptides from the thermolysin digest of chicken muscle and the peptic digest of ovalbumin were isolated. However, some of them failed to show antihypertensive activity in spontaneously hypertensive rats (SHR). To clarify this discrepancy, ACE‐inhibitory peptides from various sources were preincubated with ACE before measurement of ACE‐inhibitory activity and classified into 3 groups: (1) inhibitor type, IC 50 values of peptides that are not affected after preincubation with ACE; (2) substrate type, peptides that are hydrolyzed by ACE to give peptides with weaker activity; and (3) prodrug‐type inhibitor, these peptides are converted to true inhibitors by ACE or gastrointestinal proteases. Peptides belonging to the 1st and the 3rd groups exert antihypertensive activities even after oral administration in SHR.
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Citations
Cited by
The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease
Erdmann, K., Cheung, B. W. Y., & Schröder, H. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.11.010 · Cited by 717
Wu, J., Aluko, R. E., & Nakai, S. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051263l · Cited by 561
Abeyrathne, E. D. N. S., Lee, H. Y., & Ahn, D. U. (2013) · Poultry Science · doi:10.3382/ps.2013-03391 · Cited by 532
“Fujita et al. (2000) hydrolyzed ovalbumin with pepsin, trypsin, and α-chymotrypsin and produced 7 ACE-inhibitory peptides, which includes LKA, LKP, LAP, IKW, FQKPKR, FKGRYYP, and IVGRPRHQG.”
(2007) · doi:10.1007/978-3-540-37885-3 · Cited by 476
Cowpea: an overview on its nutritional facts and health benefits
Jayathilake, C., Visvanathan, R., Deen, A., Bangamuwage, R., Jayawardana, B. C., Nammi, S., & Liyanage, R. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9074 · Cited by 336
Metadata
- Authors
- Iroyukifujita, H., Eiichiyokoyama, K., & Yoshikawa, M.
- Venue
- Journal of Food Science
- Publisher
- Wiley
- Published
- 2000-05
- Volume
- 65
- Issue
- 4
- Pages
- 564-569
- ISSN
- 0022-1147 (ISSN-L)
- 1750-3841
- OpenAlex
- W2052418725
- Cited by
- 543
- References
- 0
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Iroyukifujita, H., Eiichiyokoyama, K., & Yoshikawa, M. (2000). Classification and Antihypertensive Activity of Angiotensin I‐Converting Enzyme Inhibitory Peptides Derived from Food Proteins. Journal of Food Science. https://doi.org/10.1111/j.1365-2621.2000.tb16049.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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