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Cited by 204

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Factors affecting antibacterial activity of hop compounds and their derivatives

Simpson, W.J., Smith, A.R.W.·1992·Journal of Applied Bacteriology

Abstract

W.J. SIMPSON AND A.R.W. SMITH. 1992. The antibacterial effect of weak acids derived from the hop plant ( Humulus lupulus L.) increased with decreasing pH. Analysis of the minimum inhibitory concentration of such compounds against Lactobacillus brevis IFO 3960 over pH4–7 suggests that undissociated molecules were mainly responsible for inhibition of bacterial growth. The antibacterial activity of trans ‐isohumulone was ca 20 times greater than that of humulone, 11 times greater than that of colupulone and nine times greater than that of trans ‐humulinic acid when the degree of ionization was taken into account. Monovalent cations (K+, Na+, NH 4 +, Rb+, Li+) stimulated antibacterial activity of trans ‐isohumulone but the effect was smaller than that observed with H+. The response to divalent cations varied: Ca2+ had little effect on antibacterial activity, whereas Mg2+ reduced activit. Lipid materials and β‐cyclodextrin also antagonized the antibacterial action of trans ‐isohumulone.

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Metadata

Authors
Simpson, W. J., & Smith, A. R. W.
Venue
Journal of Applied Bacteriology
Publisher
Wiley
Published
1992-04
Volume
72
Issue
4
Pages
327-334
ISSN
0021-8847 (ISSN-L)
OpenAlex
W2080655099
Cited by
204
References
1
FWCI
3.73
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Factors affecting antibacterial activity of hop compounds and their derivatives. https://app.cochat.ai/papers/10.1111/j.1365-2672.1992.tb01843.x
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Simpson, W. J., & Smith, A. R. W. (1992). Factors affecting antibacterial activity of hop compounds and their derivatives. Journal of Applied Bacteriology. https://doi.org/10.1111/j.1365-2672.1992.tb01843.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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