The DOI matches its Crossref record; 176 of the 176 references it cites were found in a registry or an index.
Augmentation strategies for treatment-resistant depression: a literature review: Augmentation strategies for TRD
Abstract
BACKGROUND: The large majority of depressed patients fail to remit on the first antidepressant prescribed. These patients with residual symptoms have higher relapse rates and poorer outcomes than those who remit. Treatment-resistant depression (TRD) is a therapeutic challenge for the clinician. Augmentation pharmacotherapy refers to the addition of drugs that are not standard antidepressants in order to enhance the effect of a classical antidepressant drug. The aim of this paper was to review the available evidence on the various augmenting agents that have been tested for efficacy in TRD. METHODS: Electronic databases and relevant textbooks were searched and the information retrieved was integrated in this review. RESULTS: Although augmentation strategies have been tested with various pharmacological agents, there are few controlled studies published. Lithium, triiodothyronine (T3), buspirone and pindolol have been most widely studied. Other agents include dopaminergic agents, atypical antipsychotics, psychostimulants, benzodiazepines/hypnotics, hormones and anticonvulsants. CONCLUSION: The augmentation therapy with the best evidence was the lithium-antidepressant combination, especially in patients not responding to tricyclic agents. However, good results have also been reported with augmentation strategies involving T3 and buspirone.
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“Only a subset of individuals with MDD (30–40 %) reach symptomatic remission after adequate treatment with a first-line antidepressant, and many patients do not reach premorbid levels of psychosocial functioning, such that a significant proportion of patients present residual symptoms.”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [12]
In the citing paper
“In addition, a significant proportion of patients with MDD do not recover baseline levels of psychosocial functioning even when they meet the conventional definition of remission (e.g. a score ≤7 on the Hamilton Depression Rating Scale (HDRS)) [2, 11, 12], suggesting that non-affective dimensions and domains are critical determinants of functional outcome.”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [12]
Citations
Cites
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
The Corticosteroid Receptor Hypothesis of Depression
Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181
Diagnosis and definition of treatment-resistant depression
Fava, M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00231-2 · Cited by 1,380
Omega 3 Fatty Acids in Bipolar Disorder: A Preliminary Double-blind, Placebo-Controlled Trial
Stoll, A. L., Severus, W. E., Freeman, M. P., Rueter, S., Zboyan, H. A., Diamond, E., Cress, K. K., & Marangell, L. B. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.5.407 · Cited by 814
Remission rates during treatment with venlafaxine or selective serotonin reuptake inhibitors
Thase, M. E., Entsuah, A. R., & Rudolph, R. L. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.3.234 · Cited by 801
DEFINITION AND EPIDEMIOLOGY OF TREATMENT-RESISTANT DEPRESSION
Fava, M., & Davidson, K. G. (1996) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70283-5 · Cited by 797
Residual symptoms after partial remission: an important outcome in depression
Paykel, E. S., Ramana, R., Cooper, Z., Hayhurst, H., Kerr, J., & Barocka, A. (1995) · Psychological Medicine · doi:10.1017/s0033291700033146 · Cited by 791
(1997) · PubMed · Cited by 727
Mathur, R. (2004) · Jaypee Brothers Medical Publishers (P) Ltd. eBooks · doi:10.5005/jp/books/10243_6 · Cited by 669
Research works printed but not linked: 1
- Dunner, 2003, Adjunctive ziprasidone in treatment-resident depression: a pilot study
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Genetic Tests for Depression Treatment
Lahutina, S. (2019) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.26766/pmgp.v4i3-4.223
Wendt, J. A., Considine, C., & Kogan, M. (2021) · Springer eBooks · doi:10.1007/978-3-030-81758-9_8
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Huynh, N., & McIntyre, R. S. (2009) · Medical psychiatry · doi:10.3109/9781420084887.005
Taurines, R., & Wewetzer, C. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1501-5_14
Gabriel, F. C. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.9.2022.tde-14022023-162448
Effects of fish oil supplementation on bone turnover markers in depression: a pilot study
Wang, F., Yuan, H. S., Jin, K., Tang, H., Guo, J., Wang, C., Chen, J., Dong, F., & Wang, L. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1464526
Lithium Prescription in Unipolar Depression: Findings from a Nationwide Greek Cohort Study
Karageorgiou, V., Michopoulos, I., Hadjulis, M., Mitrou, P., Thireos, E., Mathioudakis, K., Skapinakis, P., & Gournellis, R. J. (2026) · Pharmacopsychiatry · doi:10.1055/a-2924-4384
Metadata
- Authors
- Carvalho, A. F., Cavalcante, J. L., Castelo, M. S., & Lima, M. C. O.
- Affiliations
- Universidade Federal do Ceará (BR)
- Henry Ford Health (US)
- Venue
- Journal of Clinical Pharmacy and Therapeutics
- Publisher
- Wiley
- Published
- 2007-09-14
- Volume
- 32
- Issue
- 5
- Pages
- 415-428
- ISSN
- 0269-4727 (ISSN-L)
- 1365-2710
- OpenAlex
- W1623415077
- Cited by
- 110
- References
- 176
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 2 · 2017: 3 · 2016: 8 · 2015: 6 · 2014: 10 · 2013: 12 · 2012: 10
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Pharmacy and Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- treatment-resistant depression, augmentation therapy, antidepressant augmentation, lithium, triiodothyronine, buspirone, pindolol, atypical antipsychotics, psychostimulants, benzodiazepines, antiepileptic drugs, tricyclic antidepressants, residual depressive symptoms
- MeSH terms
- Central Nervous System Stimulants, Anticonvulsants, Antidepressive Agents, Benzodiazepines, Buspirone, Depressive Disorder, Drug Resistance, Drug Synergism, Drug Therapy, Combination, Humans, Hypnotics and Sedatives, Pindolol, Antipsychotic Agents, Triiodothyronine, Dopamine Agents, Lithium Compounds
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