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Adjunctive topiramate enhances the risk of hypothermia associated with valproic acid therapy
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“Another important consideration is that patients with severe CP often have compounding risk factors, including decreased muscle mass, impaired shivering response, limited voluntary control of clothing/environment, PEG dependence and malnutrition, reducing metabolic heat production, and chronic antiepileptic therapy modulating CNS neurotransmitters involved in temperature regulation [7-10].”
From Recurrent Severe Hypothermia as a Manifestation of Central Thermoregulatory Dysfunction in a Patient With Cerebral Palsy and Shaken Baby Syndrome (2026) · cites this paper as [10]
In the citing paper
“Another important consideration is that patients with severe CP often have compounding risk factors, including decreased muscle mass, impaired shivering response, limited voluntary control of clothing/environment, PEG dependence and malnutrition, reducing metabolic heat production, and chronic antiepileptic therapy modulating CNS neurotransmitters involved in temperature regulation [7-10].”
From Recurrent Severe Hypothermia as a Manifestation of Central Thermoregulatory Dysfunction in a Patient With Cerebral Palsy and Shaken Baby Syndrome (2026) · cites this paper as [10]
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Research works printed but not linked: 19
- Danzl, 2002, Hypothermia, Seminars in Respiratory and Critical Care Medicine, 23, 57, 10.1055/s-2002-20589 · DOI
- Tanelian, 1993, The role of the GABAA receptor/chloride channel complex in anesthesia, Anesthesiology, 78, 757, 10.1097/00000542-199304000-00020 · DOI · Paper page
- Jurd, 2003, General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit, FASEB Journal, 17, 250, 10.1096/fj.02-0611fje · DOI · Paper page
- Dodgson, 2000, Topiramate as an inhibitor of carbonic anhydrase isoenzymes, Epilepsia, 41, S35, 10.1111/j.1528-1157.2000.tb06047.x · DOI · Paper page
- Nishimori, 2005, Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors, Journal of Medicinal Chemistry, 48, 7860, 10.1021/jm050483n · DOI
- White, 1997, Topiramate enhances GABA-mediated chloride influx and GABA-evoked currents in mouse brain neurons and increases seizure threshold, Epilepsy Research, 28, 167, 10.1016/S0920-1211(97)00045-4 · DOI · Paper page
- Szarfman, 2002, Use of screening algorithms and computer systems to efficiently signal higher-than-expected combinations of drugs and events in the US FDA’s spontaneous reports database, Drug Safety, 25, 381, 10.2165/00002018-200225060-00001 · DOI · Paper page
- Longin, 2002, Topiramate enhances the risk of valproate-associated side effects in three children, Epilepsia, 43, 451, 10.1046/j.1528-1157.2002.42401.x · DOI
- Wegerer, 2005, Recurrent prolonged impairment of consciousness and hypothermia due to valproate treatment in a female patient with severe mental retardation, Epilepsia, 46, 44
- Stowe, 2000, Acute mental changes and hyperchloremic metabolic acidosis with long term topiramate therapy, Pharmacotherapy, 20, 105, 10.1592/phco.20.1.105.34662 · DOI
- Zachariah, 2000, Hypothermia and thermoregulatory derangements induced by valproic acid, Neurology, 55, 150, 10.1212/WNL.55.1.150 · DOI
- Kempainen, 2004, The evaluation and management of accidental hypothermia, Respiratory Care, 49, 192
- Blass, 2004, Olanzapine-associated hypothermia, Psychosomatics, 45, 135, 10.1176/appi.psy.45.2.135 · DOI
- Young, 1996, Risk factors for hypothermia in psychiatric patients, Annals of Clinical Psychiatry, 8, 93, 10.3109/10401239609148807 · DOI
- Jackson, 1959, Hypothermia IV. Study of hypothermia induction time with various pharmacological agents, Proceedings of the Society for Experimental Biology and Medicine, 100, 332, 10.3181/00379727-100-24617 · DOI
- Zeng, 2000, Role of bicarbonate ion in mediating decreased synaptic conductance in benzodiazepine tolerant hippocampal CA1 pyramidal neurons, Brain Research, 868, 202, 10.1016/S0006-8993(00)02330-1 · DOI
- Pasternak, 1992, Influence of extracellular and intracellular pH on GABA-gated chloride conductance in crayfish muscle fibers, Neuroscience, 47, 921, 10.1016/0306-4522(92)90040-9 · DOI
- Huang, 2004, Molecular basis for modulation of recombinant α1β2 γ2 GABAA receptors by protons, Journal of Neurophysiology, 92, 883, 10.1152/jn.01040.2003 · DOI
- Pasternack, 1996, Proton modulation of functionally distinct GABAA receptors in acutely isolated pyramidal neurons of rat hippocampus, Neuropharmacology, 35, 1279, 10.1016/S0028-3908(96)00075-5 · DOI
Cited by
Allnutt, B., Petrasko, P., & Jacob, R. (2026) · Cureus · doi:10.7759/cureus.102330
Metadata
- Authors
- Knudsen, J. F., Sokol, G. H., & Flowers, C. M.
- Venue
- Journal of Clinical Pharmacy and Therapeutics
- Publisher
- Hindawi Limited
- Published
- 2008-10
- Volume
- 33
- Issue
- 5
- Pages
- 513-519
- ISSN
- 0269-4727
- 1365-2710
- Cited by
- 30
- References
- 0
- Language
- en
- Licence
- doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2526 d)
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
