Iron deficiency: does it matter?
Abstract
Iron deficiency causes different abnormalities in the three major population groups that are at risk. In pregnant women, epidemiological studies suggest that anaemia, presumably due mainly to iron deficiency, is associated with an increased risk of low birth weight, prematurity, and perinatal mortality. In iron-deficient infants and children, there is convincing evidence of impaired psychomotor development and cognitive performance. Finally, iron-deficient women during the childbearing years (and iron-deficient men) have a decreased work capacity and less efficient response to exercise. These symptoms provide ample justification for preventing and treating a common and easily correctable nutritional disorder.
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In trials where a proportion of participants were anaemic at enrolment, iron supplementation has previously been associated with improved maximal and submaximal exercise performance.
“In trials where a proportion of participants were anaemic at enrolment and with the knowledge that anaemia results in decreased physical capacity, iron supplementation has previously been associated with improved maximal and submaximal exercise performance.5–8”
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Houston, B. L., Hurrie, D., Graham, J., Perija, B., Rimmer, E., Rabbani, R., Bernstein, C. N., Turgeon, A. F., Fergusson, D. A., Houston, D. S., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-019240 · Cited by 126 · see citing works
Datz, C., Haas, T., Rinner, H., Sandhofer, F., Patsch, W., & Paulweber, B. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.12.2429 · Cited by 119 · see citing works
- Authors
- DALLMAN, P. R.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- DALLMAN, P. R.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 1989-11
- Volume
- 226
- Issue
- 5
- Pages
- 367-372
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W1994318458
- Cited by
- 92
- References
- 0
- Citations by year
- 2020: 4 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 2 · 2013: 2 · 2012: 3
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-13-897)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- iron deficiency, anemia, low birth weight, preterm birth, perinatal mortality, psychomotor development, cognitive performance, work capacity, exercise capacity, iron deficiency prevention, iron deficiency treatment, pregnant women, children
- MeSH terms
- Iron Deficiencies, Anemia, Hypochromic, Child, Child, Preschool, Cognition Disorders, Female, Embryonic and Fetal Development, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Iron, Male, Physical Fitness, Pregnancy, Pregnancy Complications, Hematologic, Psychomotor Disorders, Task Performance and Analysis, Exercise
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