Gender differences and temporal variation in the incidence of type 1 diabetes: results of 8012 cases in the nationwide Diabetes Incidence Study in Sweden 1983–2002
Abstract
Objectives To establish the gender difference amongst newly diagnosed type 1 diabetic patients aged 15-34 years, considering age at diagnosis, temporal trend and seasonal variation at time of diagnosis. Study design A population-based prospective study with a mean annual population at risk of 2.3 million. Setting All departments of medicine, endocrinology and paediatrics and primary health care units in Sweden. Subjects Incident cases of diabetes aged 15-34 years at diagnosis 1983-2002. MEASURE INSTRUMENT: Basic characteristics of patients at diagnosis were reported by the diagnosing doctor on a standardized form. Level of ascertainment was estimated at 80-90%. Results Amongst all incident cases (n = 8012), 74% was diagnosed with type 1 diabetes. The mean annual incidence rate of type 1 diabetes was 12.7/100,000, in men 16.4/100,000 and in women 8.9/100,000. The incidence of type 1 diabetes decreased slowly by increasing age but was in all age groups higher in men, yielding an overall male/female ratio of 1.8. In both genders the incidence of type 1 diabetes decreased in average of 1.0% per year. A seasonal pattern with significantly higher incidence during January-March and lower during May-July was seen in both genders. Conclusions A clear male predominance of type 1 diabetes was seen in all ages. The temporal trend and the seasonal pattern was similar in men and women. Hence, internal factors related to the gender rather than differences in the exposure to environmental fa…
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Type 1 diabetes is slightly more common in boys and men.
“Whereas most autoimmune disorders disproportionately affect women, type 1 diabetes is slightly more common in boys and men.6”
From Type 1 diabetes (2014) · cites this paper as [6]
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- Authors
- Östman, J., Lönnberg, G., Arnqvist, H. J., Blohmé, G., Bolinder, J., Schnell, A. E., Eriksson, J. W., Gudbjörnsdottir, S., Sundkvist, G., & Nyström, L.
- Affiliations
- Karolinska University Hospital (SE)
- Umeå University (SE)
- Linköping University (SE)
- Lund University (SE)
- Corresponding author
- Östman, J.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2008-01-17
- Volume
- 263
- Issue
- 4
- Pages
- 386-394
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2010218451
- Cited by
- 147
- References
- 63
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 14 · 2023: 11 · 2022: 13 · 2021: 8 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 8 · 2014: 7 · 2013: 14 · 2012: 9
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 1 diabetes, incidence, sex differences, gender bias, seasonal variation, temporal trends, age at diagnosis, young adults
- MeSH terms
- Adolescent, Adult, Diabetes Mellitus, Type 1, Female, Humans, Male, Medical Records, Prospective Studies, Seasons, Sex Factors, Sweden, Incidence, Age Distribution
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