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Cortisol Response to a Combined Dexamethasone‐Human Corticotrophin‐Releasing Hormone Challenge in Patients with Depression
Open accessAbstract
We administered a combined dexamethasone‐human corticotrophin‐releasing hormone (hCRH) challenge test to 14 in‐patients with a major depressive episode and to 14 age‐matched controls. After pretreatment with 1.5 mg dexamethasone at 2300 h the day before, 100 μg hCRH was administered iv at 1500 h. Blood samples for cortisol determinations by radioimmunoassay were drawn at 1400 h, 1430 h and 1500 h before infusion of hCRH and thereafter every 15 min until 1700 h. Cortisol secretion after injection of hCRH assessed as area under the curve was significantly increased in patients with depression when compared to controls (14.5 ± 4.3 ng × min × 1,000/ml vs 3.1 ± 2.4 ng × min × 1,000/ml). Multiple regression analysis among patients revealed a significant impact of age and severity of depression upon hCRH‐induced cortisol secretion, whereas in normal controls no significant influence of age on cortisol secretion after hCRH emerged. Our data show that in depressed patients hCRH evokes an escape from dexamethasone‐induced suppression of the pituitary‐adrenocortical activity, whereas it fails to do so among controls. This finding suggests that at the pituitary level the action of hCRH is enhanced by a factor that is less sensitive to dexamethasone suppression in depression. We postulate that this factor is vasopressin.
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“In fact, sensitivity to identify alterations of the HPA axis could be increased with a successful classification of depressed patients up to 80% [56, 57].”
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Cites
Diagnostic and Statistical Manual of Mental Disorders
&NA; (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802020-00022 · Cited by 12,603
(1976) · Medical Entomology and Zoology · Cited by 8,899
Carroll, B. J. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780260017001 · Cited by 2,243
Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin
Gillies, G. E., Linton, E. A., & Lowry, P. J. (1982) · Nature · doi:10.1038/299355a0 · Cited by 965
Gold, P. W., Loriaux, D. L., Roy, A., Kling, M. A., Calabrese, J. R., Kellner, C. H., Nieman, L. K., Post, R. M., Pickar, D., Gallucci, W. T., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142101 · Cited by 766
de Kloet, E. R., & Reul, J. M. H. M. (1987) · Psychoneuroendocrinology · doi:10.1016/0306-4530(87)90040-0 · Cited by 595
Stress Down-Regulates Corticosterone Receptors in a Site-Specific Manner in the Brain*
Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1984) · Endocrinology · doi:10.1210/endo-114-1-287 · Cited by 586
Psychiatric implications of basic and clinical studies with corticotropin-releasing factor.
Gold, P., Chrousos, G., Kellner, C., Post, R., Roy, A., Augerinos, P., Schulte, H., Oldfield, E., & Loriaux, D. (1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.5.619 · Cited by 460
Abnormal Hypothalamic–Pituitary–Adrenal Function in Anorexia Nervosa
Gold, P. W., Gwirtsman, H. E., Avgerinos, P. C., Nieman, L. K., Gallucci, W. T., Kaye, W. H., Jimerson, D. C., Ebert, M. H., Rittmaster, R. S., Loriaux, D. L., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142102 · Cited by 457
Primary structure of corticotropin-releasing factor from ovine hypothalamus
Spiess, J., Rivier, J., Rivier, C., & Vale, W. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.10.6517 · Cited by 424
Research works printed but not linked: 2
- Holsboer F, 1987, Stimulation response to corticotrophin‐releasing hormone (CRH) in patients with depression, alcoholism and panic disorder, Horm Metab Res, 16, 80
- Hays WL, 1970, Statistics
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Deuschle, M., Schmider, J., Weber, B., Standhardt, H., Körner, A., Lammers, C., Schweiger, U., Hartmann, A., & Heuser, I. (1997) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199706000-00003 · Cited by 37
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Menke, A., Arloth, J., Best, J., Namendorf, C., Gerlach, T., Czamara, D., Lucae, S., Dunlop, B. W., Crowe, T. M., Garlow, S. J., et al. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.003 · Cited by 35
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Fuß, J., Claro, L., Ising, M., Biedermann, S. V., Wiedemann, K., Stalla, G. K., Briken, P., & Auer, M. K. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.02.023 · Cited by 32
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Holsboer, F. (2001) · Biological Psychology · doi:10.1016/s0301-0511(01)00089-8 · Cited by 32
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Young, E. A., Akil, H., Haskett, R. F., & Watson, S. J. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00153-t · Cited by 30
Crossroads of corticotropin releasing hormone, corticosteroids and monoamines
van Praag, H. M. (2002) · Neurotoxicity Research · doi:10.1080/1029842021000022115 · Cited by 29
Ströhle, A., Kellner, M. B., Holsboer, F., & Wiedemann, K. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00200-x · Cited by 29
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Tsuchiyama, Y., Uchimura, N., Sakamoto, T., Maeda, H., & Kotorii, T. (1995) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.1995.tb01906.x · Cited by 28
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Self-citationDuval, F. (2004) · Encyclopédie médico-chirurgicale. Psychiatrie · doi:10.1016/s0246-1072(03)00099-3 · Cited by 21
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Dinan, T. G. (2001) · Current Opinion in Psychiatry · doi:10.1097/00001504-200101000-00009 · Cited by 20
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Rubín, R. T., Dinan, T. G., & Scott, L. V. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50099-8 · Cited by 20
Intrahypothalamic Neuroendocrine Actions of Corticotropin‐Releasing Factor
Almeida, O. F. X., Hassan, A. H., & Holsboer, F. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514368.ch8 · Cited by 17
Self-citationrTMS as treatment strategy in psychiatric disorders--neurobiological concepts.
Keck, M. (2003) · Supplements to Clinical Neurophysiology · doi:10.1016/s1567-424x(09)70213-2 · Cited by 17
Cryan, J. F., Sánchez, C., Dinan, T. G., & Borsini, F. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373861-5.00007-2 · Cited by 17
The human hypothalamo-neurohypophysial system in health and disease
Swaab, D. F. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61594-0 · Cited by 15
Stress, the Hypothalamic—Pituitary—Adrenal Axis, and Depression
Ritchie, J., & Nemeroff, C. B. (1991) · Elsevier eBooks · doi:10.1016/b978-0-12-482490-4.50013-4 · Cited by 14
The human hypothalamus in metabolic and episodic disorders
Swaab, D. F. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)53001-8 · Cited by 14
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Condren, R. M., & Thakore, J. H. (2001) · Stress · doi:10.3109/10253890109115725 · Cited by 12
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Holsboer, F. (2010) · Der Nervenarzt · doi:10.1007/s00115-010-3053-1 · Cited by 11
Self-citationGehris, T. L., Kathol, R. G., Meller, W. H., López, J. F., & Jaeckle, R. S. (1991) · Psychoneuroendocrinology · doi:10.1016/0306-4530(91)90032-o · Cited by 11
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Antoni, F. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802175-0.00009-7 · Cited by 13
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Connor, T., & Leonard, B. E. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18500-7_4 · Cited by 9
Romanholi, D. J. P. C., & Salgado, L. R. (2007) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302007000800016 · Cited by 9
Advances of paeoniflorin in depression: the molecular mechanism and formula application
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Holsboer, F., & Ising, M. (2024) · Pharmacopsychiatry · doi:10.1055/a-2372-3549 · Cited by 8
Self-citationHüfner, K., Giesinger, J. M., Gostner, J. M., Egeter, J., Koudouovoh-Tripp, P., Vill, T., Fuchs, D., & Sperner‐Unterweger, B. (2021) · International Journal of Tryptophan Research · doi:10.1177/11786469211039220 · Cited by 7
Schmider, J., Deuschle, M., Schweiger, U., Kørner, A., Gotthardt, U., & Heuser, I. J. E. (1995) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199508000-00003 · Cited by 7
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de Kloet, E. R., DeRijk, R. H., & Meijer, O. C. (2011) · Wiley eBooks · doi:10.1002/9781118083222.ch3 · Cited by 6
Holsboer‐Trachsler, E., Hemmeter, U., Stohler, R., Hatzinger, M., Gerhard, U., & Hobi, V. (1991) · European Neuropsychopharmacology · doi:10.1016/0924-977x(91)90552-6 · Cited by 5
Molekulare Mechanismen der Depressionstherapie
Holsboer, F. (1999) · Springer eBooks · doi:10.1007/978-3-662-07096-3_9 · Cited by 6
Self-citationAdvances in the drug treatment of Alzheimer's Disease
Leonard, B. E. (1998) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/(sici)1099-1077(199803)13:2 · Cited by 1
Langgartner, D., Koenen, M., Kupfer, S., Glogger, L., Kurz, L., Perez‐Rivas, L. G., Theodoropoulou, M., Noll‐Hussong, M., Vettorazzi, S., Tuckermann, J. P., et al. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100541 · Cited by 3
Intermediate glucocorticoid feedback of corticotropin secretion in patients with major depression
Kellner, M. B., Holsboer, F., & Heuser, I. (1995) · Psychiatry Research · doi:10.1016/0165-1781(96)81880-4 · Cited by 3
Self-citationKlinische und neurobiologische Effekte des Schlafentzugs
Seifritz, E., & Holsboer‐Trachsler, E. (1996) · Springer eBooks · doi:10.1007/978-3-7091-6592-8_7 · Cited by 2
de Abreu, A., de Mello, F., Mello, M. F., & Carpenter, L. L. (2003) · Cited by 2
Research Activity at the Max Planck Institute for Psychiatry (Munich): Depression in Later Life
Heuser, I. J. E., & Holsboer, F. (1991) · International Psychogeriatrics · doi:10.1017/s1041610291000546 · Cited by 1
Self-citationAmador‐Arjona, A. (2008) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Neuropeptides in hypothalamic pathology
Swaab, D. F. (1996) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9010-6_35
Die Entwicklung der Depressionsbehandlung aus psychobiologischer Sicht
Holsboer‐Trachsler, E. (1997) · Springer eBooks · doi:10.1007/978-3-642-60807-0_13
Heuser, I. J. E., Grasser, A., Gotthardt, U., Schmider, J., & Holsboer, F. (1991) · European Neuropsychopharmacology · doi:10.1016/0924-977x(91)90549-a
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Aubry, J., & Gex‐Fabry, M. (2013)
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Chiuccariello, L. (2015) · TSpace (University of Toronto)
Die Wirkungen von akutem Stress auf Erlernen und Abruf erlernter Handlungs-Ergebnis-Beziehungen
Braun, S. (2017) · OPUS Publication Server of the University of Stuttgart (University of Stuttgart) · doi:10.18419/opus-9368
Pariante, C. M., & Mondelli, V. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717949809.793455012
Sharrett-Field, L. J. (2013) · UKnowledge (University of Kentucky)
Impact of stress exposure and pharmacological intervention on a mouse model of Alzheimer’s disease
Sierksma, S. R. (2012) · Research Publications (Maastricht University) · doi:10.26481/dis.20121220ss
Metadata
- Authors
- von Bardeleben, U., & Holsboer, F.
- Affiliations
- University of Freiburg (DE)
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 1989-12
- Volume
- 1
- Issue
- 6
- Pages
- 485-488
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2069410124
- Cited by
- 161
- References
- 31
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 6 · 2012: 4
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- depression, cortisol secretion, dexamethasone suppression test, pituitary-adrenal axis, vasopressin
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