Gonadectomy reverses the sexually diergic patterns of circadian and stress-induced hypothalamic-pituitary-adrenal axis activity in male and female rats
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Enhanced corticosterone release by female compared to male rats under basal and stress conditions is well documented. The demonstration that gonadectomy enhances stress-induced corticosterone secretion in male rats, but reduces such levels in female rats, suggests a causal association between gonadal steroids and corticosterone release. The present study examined the corticosterone profile of sham gonadectomized and gonadectomized female and male rats under basal and stress conditions. An automated sampling system collected blood from each freely moving, unanaesthetized rat every 10 min (i) over a 24-h period; (ii) following noise stress; and (iii) following an immune-mediated stress (lipopolysaccharide, LPS). Plasma was analysed for corticosterone content using radioimmunoassay. Castration resulted in a significant increase in basal corticosterone release compared to the sham-castrated male rats. Pulsar analysis revealed a significant two-fold increase in the number of corticosterone pulses over 24 h. Corticosterone increases in response to noise stress and to LPS injection were enhanced following castration. Conversely, ovariectomy resulted in a two-fold reduction in the number of corticosterone pulses as well as the stress response compared to sham-ovariectomized female rats. Arginine vasopressin (AVP), corticotrophin-releasing hormone (CRH) and glucocorticoid receptor mRNAs in the paraventricular nucleus and pro-opiomelanocortin (POMC) mRNA in the anterior pituitary were…
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It is plausible that administration of leuprolide acetate, which reduces testosterone secretion, elevates corticosterone levels.
“Therefore, it is plausible that the administration of leuprolide acetate, which reduces testosterone secretion, elevates corticosterone levels (29).”
From Puberty Blocker, Leuprolide, Reduces Sex Differences in Rough-and-Tumble Play and Anxiety-like Behavior in Juvenile Rats (2024) · cites this paper as [29]
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References 55 · Cited by 243
- Authors
- Seale, J. V., Wood, S. A., Atkinson, H. C., Bate, E., Lightman, S. L., Ingram, C. D., Jessop, D. S., & Harbuz, M. S.
- Affiliations
- University of Bristol (GB)
- Newcastle University (GB)
- Corresponding author
- Seale, J. V.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2004-05-28
- Volume
- 16
- Issue
- 6
- Pages
- 516-524
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2043525975
- Cited by
- 243
- References
- 55
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 14 · 2023: 10 · 2022: 6 · 2021: 8 · 2020: 15 · 2019: 16 · 2018: 14 · 2017: 10 · 2016: 9 · 2015: 9 · 2014: 13 · 2013: 13 · 2012: 11
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- gonadectomy, castration, ovariectomy, hypothalamic-pituitary-adrenal axis, corticosterone secretion, circadian rhythm, stress response, noise stress, lipopolysaccharide, vasopressin, corticotropin-releasing factor, proopiomelanocortin, glucocorticoid receptor, paraventricular nucleus, anterior pituitary, sex differences, sex steroids, pulsatile hormone secretion
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Castration, Circadian Rhythm, Corticosterone, Female, Hypothalamo-Hypophyseal System, Male, Ovariectomy, Paraventricular Hypothalamic Nucleus, Pituitary-Adrenal System, Pro-Opiomelanocortin, RNA, Messenger, Sex Characteristics, Gonadal Steroid Hormones, Stress, Psychological, Rats, Sprague-Dawley, Rats
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