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IRE1 encodes a putative protein kinase containing a membrane‐spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae
Abstract
Summary: A novel gene, IRE1, of Saccharomyces cerevisiae was cloned through genetic complementation of a myo‐ inositol auxotrophic mutant. The predicted amino acid sequence indicated that IRE1 encodes a protein of 126983 Da with two highly hydrophobic regions, probably a signal sequence and a membrane‐spanning region. The carboxy‐terminal region of IRE1 showed close sequence similarity to the catalytic domains of protein kinases. Disruption of the IRE1 locus caused myo‐inositol auxotrophy. The IRE1 product is very likely a protein kinase required for myo‐inositol synthesis.
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Citations
Cited by
Haze, K., Yoshida, H., Yanagi, H., Yura, T., & Mori, K. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.11.3787 · Cited by 2,069
ER stress and the unfolded protein response
Schröder, M., & Kaufman, R. J. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.06.056 · Cited by 1,747
Morl, K., Ma, W., Gething, M.-J., & Sambrook, J. (1993) · Cell · doi:10.1016/0092-8674(93)90521-q · Cited by 818
The unfolded protein response in nutrient sensing and differentiation
Kaufman, R. J., Scheuner, D., Schröder, M., Shen, X., Lee, K., Liu, C. Y., & Arnold, S. M. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm829 · Cited by 607
Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway
Cullinan, S. B., & Diehl, J. A. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.09.018 · Cited by 554
Metadata
- Authors
- Nikawa, J., & Yamashita, S.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1992-06
- Volume
- 6
- Issue
- 11
- Pages
- 1441-1446
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2052321340
- Cited by
- 195
- References
- 0
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: IRE1 encodes a putative protein kinase containing a membrane‐spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae. https://app.cochat.ai/papers/10.1111/j.1365-2958.1992.tb00864.x
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- Nikawa, J., & Yamashita, S. (1992). IRE1 encodes a putative protein kinase containing a membrane‐spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.1992.tb00864.x
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