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Growth and viability of Streptomyces coelicolor mutant for the cell division gene ftsZ
Abstract
Summary: A homologue of the bacterial cell division gene ftsZ was cloned from the filamentous bacterium Streptomyces coelicolor. The gene was located on the physical map of the chromosome at about ‘11 o'clock’ (in the vicinity of glkA, hisA and trpB). Surprisingly, a null mutant in which the 399‐codon ftsZ open reading frame was largely deleted was viable, even though the mutant was blocked in septum formation. This indicates that cell division may not be essential for the growth and viability of S. coelicolor. The ftsZ mutant was able to produce aerial hyphae but was unable to produce spores, a finding consistent with the idea that ftsZ is required in order for aerial hyphae to undergo septation into the uninucleoid cells that differentiate into spores.
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Citations
Cited by
Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium
Flärdh, K., & Buttner, M. J. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro1968 · Cited by 667
Bacterial solutions to multicellularity: a tale of biofilms, filaments and fruiting bodies
Claessen, D., Rozen, D. E., Kuipers, O. P., Søgaard-Andersen, L., & van Wezel, G. P. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3178 · Cited by 488
Synthetic biology to access and expand nature's chemical diversity
Smanski, M. J., Zhou, H., Claesen, J., Shen, B., Fischbach, M. A., & Voigt, C. A. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.24 · Cited by 481
BACTERIAL CELL DIVISION AND THE Z RING
Lutkenhaus, J., & Addinall, S. G. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.93 · Cited by 465
Bacterial Growth and Cell Division: a Mycobacterial Perspective
Hett, E. C., & Rubin, E. J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00028-07 · Cited by 408
Metadata
- Authors
- McCormick, J. R., Su, E. P., Driks, A., & Losick, R.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1994-10
- Volume
- 14
- Issue
- 2
- Pages
- 243-254
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2039616785
- Cited by
- 182
- References
- 0
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Growth and viability of Streptomyces coelicolor mutant for the cell division gene ftsZ. https://app.cochat.ai/papers/10.1111/j.1365-2958.1994.tb01285.x
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- McCormick, J. R., Su, E. P., Driks, A., & Losick, R. (1994). Growth and viability of Streptomyces coelicolor mutant for the cell division gene ftsZ. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.1994.tb01285.x
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