The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cyclic diguanylate (c‐di‐GMP) regulates Vibrio cholerae biofilm formation
Open accessAbstract
Summary: While studying virulence gene regulation in Vibrio cholerae during infection of the host small intestine, we identified VieA as a two‐component response regulator that contributes to activating expression of cholera toxin. Here we report that VieA represses transcription of Vibrio exopolysaccharide synthesis ( vps ) genes involved in biofilm formation by a mechanism independent of its phosphorelay and DNA‐binding activities. VieA controls the intracellular concentration of the cyclic nucleotide second messenger cyclic diguanylate (c‐di‐GMP) using an EAL domain that functions as a c‐di‐GMP phosphodiesterase. Two‐dimensional thin layer chromatography of nucleotide extracts confirmed that VieA reduces the concentration of c‐di‐GMP, opposing the action of c‐di‐GMP synthetase proteins. Expression of unrelated V. cholerae c‐di‐GMP synthetase or phosphodiesterae proteins also modulated c‐di‐GMP concentration and vps gene expression. We propose that c‐di‐GMP synthetase and phosphodiesterase domain‐containing proteins contribute to regulating biofilm formation by controlling c‐di‐GMP concentration.
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Cites
Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation
Drenkard, E., & Ausubel, F. M. (2002) · Nature · doi:10.1038/416740a · Cited by 997
Cited by
Hickman, J. W., Tifrea, D. F., & Harwood, C. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507170102 · Cited by 836
Molecular Mechanisms of Two-Component Signal Transduction
Zschiedrich, C. P., Keidel, V., & Szurmant, H. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.08.003 · Cited by 540
Barraud, N., Schleheck, D., Klebensberger, J., Webb, J. S., Hassett, D. J., Rice, S. A., & Kjelleberg, S. (2009) · Journal of Bacteriology · doi:10.1128/jb.00975-09 · Cited by 513
Roles of Cyclic Diguanylate in the Regulation of Bacterial Pathogenesis
Tamayo, R., Pratt, J. T., & Camilli, A. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093426 · Cited by 486
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Metadata
- Authors
- Tischler, A. D., & Camilli, A.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2004-06-28
- Volume
- 53
- Issue
- 3
- Pages
- 857-869
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2146429915
- Cited by
- 502
- References
- 1
- FWCI
- 9.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tischler, A. D., & Camilli, A. (2004). Cyclic diguanylate (c‐di‐GMP) regulates Vibrio cholerae biofilm formation. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2004.04155.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
