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Cited by 198Photosynthetic Processes and MechanismsPhotoreceptor and optogenetics researchPorphyrin and Phthalocyanine Chemistry

Biliprotein maturation: the chromophore attachment

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Scheer, H., Zhao, K.‐H.·2008·Molecular Microbiology
DOI 10.1111/j.1365-2958.2008.06160.xPMC PMC2327270
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Abstract

Summary: Biliproteins are a widespread group of brilliantly coloured photoreceptors characterized by linear tetrapyrrolic chromophores, bilins, which are covalently bound to the apoproteins via relatively stable thioether bonds. Covalent binding stabilizes the chromoproteins and is mandatory for phycobilisome assembly; and, it is also important in biliprotein applications such as fluorescence labelling. Covalent binding has, on the other hand, also considerably hindered biliprotein research because autocatalytic chromophore additions are rare, and information on enzymatic addition by lyases was limited to a single example, an EF‐type lyase attaching phycocyanobilin to cysteine‐α84 of C‐phycocyanin. The discovery of new activities for the latter lyases, and of new types of lyases, have reinvigorated research activities in the subject. So far, work has mainly concentrated on cyanobacterial phycobiliproteins. Methodological advances in the process, however, as well as the finding of often large numbers of homologues, opens new possibilities for research on the subsequent assembly/disassembly of the phycobilisome in cyanobacteria and red algae, on the assembly and organization of the cryptophyte light‐harvesting system, on applications in basic research such as protein folding, and on the use of phycobiliproteins for labelling.

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  • Phycoerythrins are water-soluble protein compounds that have many beneficial effects on health.

    “Phycoerythrins are water-soluble protein compounds that have many beneficial effects on one’s health”

    From Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review. (2022) · cites this paper as [96]

    The Introduction describes phycoerythrins as phycobiliproteins and explains their role in photosynthetic light harvesting. Our copy does not establish that they are water-soluble or report beneficial effects on human health (searched for water solubility and health benefits). (LLM, conf=0.82)

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  • C-phycocyanin accounts for around 20% of the dry weight of spirulina and is sold commercially as an antioxidant, anti-inflammatory agent, and natural colorant.

    “The primary pigment is called C-phycocyanin, and it accounts for around 20% of the dry weight of the substance. It is also sold in the commercial world as an antioxidant and an anti-inflammatory agent, in addition to its usage as a natural colorant.”

    From Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review. (2022) · cites this paper as [96]

    The Chromophore detachment section mentions C-phycocyanin in Spirulina in connection with its proteolysis, and the References list a structural study of C-phycocyanin from Spirulina platensis. Neither passage addresses the claimed 20% dry-weight figure or commercial sales as an antioxidant, anti-inflammatory agent, or natural colorant. Searches for those terms found no supporting passage in our copy. (LLM, conf=0.76)

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Research works printed but not linked: 95

  1. [1]Adir N Vainer R Lerner N Refined structure of c-phycocyanin from the cyanobacterium Synechococcus vulcanus at 1.6 A: insights into the role of solvent molecules in thermal stability and co-factor structure Biochim Biophys Acta 2002 1556 168 174 12460674
  2. Anderson LK Toole CM A model for early events in the assembly pathway of cyanobacterial phycobilisomes Mol Microbiol 1998 30 467 474 9822813
  3. Apt KE Collier JL Grossman AR Evolution of phycobiliproteins J Mol Biol 1995 248 79 96 7731046
  4. Arciero DM Bryant DA Glazer AN In vitro attachment of Bilins to Apophycocyanin. 1. Specific covalent adduct formation at Cysteinyl residues involved in Phycocyanobilin binding in C-Phycocyanin J Biol Chem 1988 263 18343 18349 3142876
  5. Balabas BE Montgomery BL Ong LE Kehoe DM CotB is essential for complete activation of green light-induced genes during complementary chromatic adaptation in Fremyella diplosiphon Mol Microbiol 2003 50 781 793 14617141
  6. Beale SI Cornejo J Biosynthesis of phycobilins. Ferredoxin-mediated reduction of biliverdin catalyzed by extracts of Cyanidium caldarium J Biol Chem 1991 266 22328 22332 1939255
  7. Bienert R Baier K Volkmer R Lockau W Heinemann U Crystal structure of NblA from Anabaena sp. PCC 7120, a small protein playing a key role in phycobilisome degradation J Biol Chem 2006 281 5216 5223 16356935
  8. Böhm S Endres S Scheer H Zhao K-H Biliprotein chromophore attachment: chaperone-like function of PecE-subunit of α-phycoerythrocyanin lyaseE J Biol Chem 2007 282 25357 25366 17595164
  9. Cobley JG Clark AC Weerasurya S Queseda FA Xiao JY Bandrapali N CpeR is an activator required for expression of the phycoerythrin operon (cpeBA) in the cyanobacterium Fremyella diplosiphon and is encoded in the phycoerythrin linker-polypeptide operon (cpeCDESTR) Mol Microbiol 2002 44 1517 1531 12067341
  10. Daltrop O Allen JW Willis AC Ferguson SJ In vitro formation of a c-type cytochrome Proc Natl Acad Sci USA 2002 99 7872 7876 12060734 PMC122987
  11. Dammeyer T Frankenberg-Dinkel N Insights into phycoerythrobilin biosynthesis point toward metabolic channeling J Biol Chem 2006 281 27081 27089 16857683
  12. Dammeyer T Bagby SC Sullivan MB Chisholm SW Frankenberg-Dinkel N Efficient phage-mediated pigment biosynthesis in oceanic cyanobacteria Curr Biol 2008 in press 18356052
  13. De Lorimier R Wilbanks SM Glazer AN Genes of the R-Phycocyanin II locus of marine Synechococcus spp. & comparison of protein–chromophore interactions in Phycocyanins differing in Bilin composition Plant Mol Biol 1993 21 225 237 8425055
  14. Dolganov N Grossman AR A polypeptide with similarity to phycocyanin alpha-subunit phycocyanobilin lyase involved in degradation of phycobilisomes J Bacteriol 1999 181 610 617 9882677 PMC93417
  15. Doust AB Marai CNJ Harrop SJ Wilk KE Curmi PMB Scholes GD Developing a structure–function model for the cryptophyte phycoerythrin 545 using ultrahigh resolution crystallography and ultrafast laser spectroscopy J Mol Biol 2004 344 135 153 15504407
  16. Everroad C Six C Partensky F Thomas JC Holtzendorff J Wood AM Biochemical bases of type IV chromatic adaptation in marine Synechococcus spp J Bacteriol 2006 188 3345 3356 16621829 PMC1447437
  17. Fairchild CD Glazer AN Nonenzymatic bilin addition to the gamma subunit of an apophycoerythrin J Biol Chem 1994a 269 28988 28996 7961862
  18. Fairchild CD Glazer AN Oligomeric structure, enzyme kinetics, and substrate specificity of the phycocyanin alpha subunit phycocyanobilin lyase J Biol Chem 1994b 269 8686 8694 8132596
  19. Fairchild CD Zhao J Zhou J Colson SE Bryant DA Glazer AN Phycocyanin α-subunit phycocyanobilin lyase Proc Natl Acad Sci USA 1992 89 7017 7021 1495995 PMC49636
  20. Falk H The Chemistry of Linear Oligopyrroles and Bile Pigments 1989 Wien, New York Springer
  21. Ficner R Huber R Refined crystal structure of phycoerythrin from Porphyridium cruentum at 2.3 Angström resolution and localization of the gamma subunit Eur J Biochem 1993 218 103 106 8243457
  22. Frankenberg N Lagarias JC Kadish KM Smith KM Guilard R Biosynthesis and biological functions of bilins The Porphyrin Handbook 2003a Amsterdam Academic Press 211 236
  23. Frankenberg N Lagarias JC Phycocyanobilin: ferredoxin oxidoreductase of Anabaena sp. PCC 7120. Biochemical and spectroscopic J Biol Chem 2003b 278 9219 9226 12514179
  24. Gindt YM Zhou J Bryant DA Sauer K Core mutations of Synechococcus sp. PCC 7002 phycobilisomes: a spectroscopic study J Photochem Photobiol B 1992 15 75 89 1460543
  25. Gindt YM Zhou JH Bryant DA Sauer K Spectroscopic studies of phycobilisome subcore preparations lacking key core chromophores: assignment of excited state energies to the L(cm), beta(18) and alpha(AP-B) chromophores Biochim Biophys Acta 1994 1186 153 162 8043589
  26. Glazer AN Stryer L Fluorescent tandem phycobiliprotein conjugates. Emission wavelength shifting by energy transfer Biophys J 1983 43 383 386 6414547 PMC1329306
  27. Hess WR Partensky F van der Staay GW Garcia-Fernandez JM Borner T Vaulot D Coexistence of phycoerythrin and a chlorophyll a/b antenna in a marine prokaryote Proc Natl Acad Sci USA 1996 93 11126 11130 8855320 PMC38295
  28. Hess WR Steglich C Lichtlé C Partensky F Phycoerythrins of the oxyphotobacterium Prochlorococcus marinus are associated to the thylakoid membrane and are encoded by a single large gene cluster Plant Mol Biol 1999 40 507 521 10437834
  29. Hess WR Rocap G Ting CS Larimer F Stilwagen S Lamerdin J Chisholm SW The photosynthetic apparatus of Prochlorococcus: insights through comparative genomics Photosynth Res 2001 70 53 71 16228362
  30. Hu IC Lee TR Lin HF Chiueh CC Lyu PC Biosynthesis of fluorescent allophycocyanin alpha-subunits by autocatalytic bilin attachment Biochemistry 2006 45 7092 7099 16752899
  31. Inomata K Noack S Hammam MA Khawn H Kinoshita H Murata Y Assembly of synthetic locked chromophores with Agrobacterium phytochromes Agp1 and Agp2 J Biol Chem 2006 281 28162 28173 16803878
  32. Ishizuka T Narikawa R Kohchi T Katayama M Ikeuchi M Cyanobacteriochrome TePixJ of Thermosynechococcus elongatus harbors phycoviolobilin as a chromophore Plant Cell Physiol 2007 48 1385 1390 17715149
  33. Jorissen HJ Quest B Lindner I Tandeau de Marsac N Gärtner W Phytochromes with noncovalently bound chromophores: the ability of apophytochromes to direct tetrapyrrole photoisomerization Photochem Photobiol 2002 75 554 559 12017484
  34. Julien O Gignac I Hutton A Yee A Arrowsmith CH Gagne SM MTH187 from Methanobacterium thermoautotrophicum has three HEAT-like Repeats J Biomol NMR 2006 35 149 154 16819590
  35. Kahn K Mazel D Houmard J Tandeau de Marsac N Schaefer MR A role for cpeYZ in cyanobacterial phycoerythrin biosynthesis J Bacteriol 1997 179 998 1006 9023176 PMC178790
  36. Kaneko T Sato S Kotani H Tanaka A Asamizu E Nakamura Y Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions DNA Res 1996 3 109 136 8905231
  37. Kaneko T Nakamura Y Wolk CP Kuritz T Sasamoto S Watanabe A Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120 DNA Res 2001 8 205 213 11759840
  38. Kohchi T Mukougawa K Frankenberg N Masuda M Yokota A Lagarias JC The Arabidopsis HY2 gene encodes phytochromobilin synthase, a ferredoxin-dependent biliverdin reductase Plant Cell 2001 13 425 436 11226195 PMC102252
  39. Kupka M Scheer H Unfolding of C-Phycocyanin followed by loss of non-covalent chromophore–protein interactions: 1. Equilibrium experiments Biochim Biophys Acta 2008 1777 94 103 18036334
  40. Lamparter T Evolution of cyanobacterial and plant phytochromes FEBS Lett 2004 573 1 5 15327965
  41. Lamparter T Michael N Agrobacterium phytochrome as an enzyme for the production of ZZE bilins Biochemistry 2005 44 8461 8469 15938635
  42. Lamparter T Carrascal M Michael N Martinez E Rottwinkel G Abian J The biliverdin chromophore binds covalently to a conserved cysteine residue in the N-terminus of Agrobacterium phytochrome Agp1 Biochemistry 2004 43 3659 3669 15035636
  43. Lane CE van den Heuvel K Kozera C Curtis BA Parsons BJ Bowman S Archibald JM Nucleomorph genome of Hemiselmis andersenii reveals complete intron loss and compaction as a driver of protein structure and function (UniProtKB/TrEMBL entry A9BKE0) Proc Natl Acad Sci USA 2008 (in press). PMC2148396 18077423
  44. Liu LN Chen XL Zhang YZ Zhou BC Characterization, structure and function of linker polypeptides in phycobilisomes of cyanobacteria and red algae: an overview Biochim Biophys Acta 2005 1708 133 142 15922288
  45. Ma Y Xie J Zhang C Zhao J Three-stage refolding/unfolding of the dual-color β-subunit in R-phycocyanin from Polysiphonia urceolata Biochem Biophys Res Commun 2007 352 787 793 17141193
  46. MacColl R Cyanobacterial Phycobilisomes J Struct Biol 1998 124 311 334 10049814
  47. MacColl R Guard-Friar D Phycobiliproteins 1987 Boca Raton CRC Press
  48. Mann NH Clokie MR Millard A Cook A Wilson WH Wheatley PJ The genome of S-PM2, a ‘photosynthetic’ T4-type bacteriophage that infects marine Synechococcus strains (UniProtKB/TrEMBL entry Q5GQC2) J Bacteriol 2005 187 3188 3200 15838046 PMC1082820
  49. Montgomery BL Sensing the light: photoreactive systems and signal transduction in cyanobacteria Mol Microbiol 2007 64 16 27 17376068
  50. Montgomery BL Casey ES Grossman AR Kehoe DM AplA, a member of a new class of phycobiliproteins lacking a traditional role in photosynthetic light harvesting J Bacteriol 2004 186 7420 7428 15489454 PMC523187
  51. Nakamura Y Kaneko T Sato S Mimuro M Miyashita H Tsuchiya T Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids DNA Res 2003 10 137 145 14621292
  52. Nanni B Balestreri E Dainese E Cozzani I Felicioli R Characterisation of a specific phycocyanin-hydrolysing protease purified from Spirulina platensis Microbiol Res 2001 156 259 266 11716214
  53. Nield J Rizkallah PJ Barber J Chayen NE The 1.45 A three-dimensional structure of C-phycocyanin from the thermophilic cyanobacterium Synechococcus elongatus J Struct Biol 2003 141 149 155 12615541
  54. Oi VT Glazer AN Stryer L Flurescent phycobiliprotein conjugates for analyses of cells and molecules J Cell Biol 1982 93 981 986 6749865 PMC2112146
  55. Reuter W Wiegand G Huber R Than ME Structural analysis at 2.2 Å of orthorhombic crystals presents the asymmetry of the allophycocyanin-linker complex, AP Lc(7.8), from phycobilisomes of Mastigocladus laminosus Proc Natl Acad Sci USA 1999 96 1363 1368 9990029 PMC15468
  56. Ritter S Hiller RG Wrench PM Welte W Diederichs K Crystal structure of a phycourobilin-containing phycoerythrin at 1.90 a resolution J Struct Biol 1999 126 86 97 10388620
  57. Rocap G Larimer FW Lamerdin JE Malfatti S Chain P Ahlgren NA Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation (UniProtKB/TrEMBL entry Q7V2Z2) Nature 2003 424 1042 1047 12917642
  58. Rockwell NC Su YS Lagarias JC Phytochrome structure and signaling mechanisms Ann Rev Plant Biol 2006 57 837 858 16669784 PMC2664748
  59. Saunée NA Williams SR Bryant DA Schluchter WM Biogenesis of phycobiliproteins. II. CpcS and CpcU comprise the heterodimeric bilin lyase that attaches phycocyanobilin to Cys-82 of β-phycocyanin and Cys-81 of allophycocyanin subunits in Synechococcus sp. PCC 7002 J Biol Chem 2008 283 in press. 10.1074/jbc. M708165200 PMC2276331 18199753 · DOI
  60. Scheer H Fong FK Phycobiliproteins: molecular aspects of photosynthetic antenna systems Light Reaction Path of Photosynthesis 1982 Berlin Springer 7 45
  61. Schirmer T Bode W Huber R Refined three-dimensional structures of two cyanobacterial C-phycocyanins at 2.1. and 2.5 A resolution – a common principle of phycobilin–protein interaction J Mol Biol 1987 196 677 695 3119857
  62. Schluchter WM Glazer AN Peschek GA Löffelhardt W Schmetterer G Biosynthesis of phycobiliproteins in cyanobacteria The Phototrophic Prokaryotes 1999 New York Kluwer/Plenum Press 83 95
  63. Schluchter WM Bryant DA Smith AG Witty M Analysis and reconstitution of phycobiliproteins. methods for the characterization of bilin attachment reactions Heme, Chlorophyll, and Bilins 2002 Totowa, NJ Humana Press 311 334
  64. Schmidt M Patel A Zhao Y Reuter W Structural basis for the photochemistry of α-Phycoerythrocyanin Biochemistry 2007 46 416 423 17209552
  65. Shaltiel S Thiolysis of some dinitrophenyl derivatives of amino acids Biochem Biophys Res Commun 1967 29 178 183 6066276
  66. Shen G Saunee NA Gallo E Begovic Z Schluchter WM Bryant DA Niederman RA Blankenship RE Frank H Robert B van Grondelle R Identification of novel phycobiliprotein lyases in cyanobacteria PS 2004 Light-Harvesting Systems Workshop 2004 Saint Adele, Québec, Canada International Society of Photosynthesis Research 14 15
  67. Shen G Saunee NA Williams SR Gallo EF Schluchter WM Bryant DA Identification and characterization of a new class of bilin lyase. the cpcT gene encodes a bilin lyase responsible for attachment of phycocyanobilin to Cys-153 on the beta subunit of phycocyanin in Synechococcus sp. PCC 7002 J Biol Chem 2006 281 17768 17778 16644722
  68. Shen G Schluchter WM Bryant DA Biogenesis of phycobiliproteins. I. cpcS and cpcU mutants of the cyanobacterium, Synechococcus sp. PCC 7002 define a heterodimeric phycocyanobilin lyase specific for β-phycocyanin and allophycocyanin subunits J Biol Chem 2008 283 in press. doi: 10.1074/jbc. M708164200 18199754 · DOI
  69. Six C Thomas J-C Thion L Lemoine Y Zal F Partensky F Characterization of two novel phycoerythrin-associated linker proteins in the marine cyanobacterium Synechococcus sp. WH8102 J Bacteriol 2005 187 1685 1694 15716439 PMC1064003
  70. Stec B Troxler RF Teeter MM Crystal structure of C-phycocyanin from Cyanidium caldarium provides an new perspective on phycobilisome assembly Biophys J 1999 76 2912 2921 10354419 PMC1300263
  71. Swanson RV Glazer AN Phycobiliprotein methylation: effect of the gamma-N-Methylasparagine residue on energy transfer in Phycocyanin and the Phycobilisome J Mol Biol 1990 214 787 796 2117667
  72. Swanson RV Zhou J Leary JA Williams T de Lorimier R Bryant DA Glazer AN Characterization of phycocyanin produced by cpcE and cpcF mutants and identification of an intergenic suppressor of the defect in bilin attachment J Biol Chem 1992 267 16146 16154 1644802
  73. Tandeau de Marsac N Cohen-Bazire G Molecular composition of cyanobacterial phycobilisomes Proc Natl Acad Sci USA 1977 74 1635 1639 404640 PMC430846
  74. Toole CM Plank TL Grossman AR Anderson LK Bilin deletions and subunit stability in cyanobacterial light-harvesting proteins Mol Microbiol 1998 30 475 486 9822814
  75. Tooley AJ Glazer AN Biosynthesis of the cyanobacterial light-harvesting polypeptide phycoerythrocyanin holo-α subunit in a heterologous host J Bacteriol 2002 184 4666 4671 12169589 PMC135287
  76. Tooley AJ Cai YA Glazer AN Biosynthesis of a fluorescent cyanobacterial C-phycocyanin holo-α subunit in a heterologous host Proc Natl Acad Sci USA 2001 98 10560 10565 11553806 PMC58505
  77. Tu J-M Kupka M Böhm S Plöscher M Eichacker L Zhao K-H Scheer H Intermediate binding of phycocyanobilin to the lyase, CpeS1, and transfer to apoprotein Photosynth Res 2008 95 163 168 17912606
  78. Turkarslan S Sanders C Daldal F Extracytoplasmic prosthetic group ligation to apoproteins: maturation of c-type cytochromes Mol Microbiol 2006 60 537 541 16629658
  79. Wagner JR Brunzelle JS Forest KT Vierstra RD A light-sensing knot revealed by the structure of the chromophore-binding domain of phytochrome Nature 2005 438 325 331 16292304
  80. Wang XQ Li LN Chang WR Zhang JP Gui LL Guo BJ Liang DC Structure of C-phycocyanin from Spirulina platensis at 2.2 Angstrom resolution: a novel monoclinic crystal form for phycobiliproteins in phycobilisomes Acta Cryst D Biol Cryst 2001 57 784 792 11375497
  81. Wemmer DE Wedemayer GJ Glazer AN Phycobilins of Cryptophycean Algae – Novel Linkage of Dihydrobiliverdin in a Phycoerythrin-555 and a Phycocyanin-645 J Biol Chem 1993 268 1658 1669 8420941
  82. Wilbanks SM Glazer AN Rod structure of a phycoerythrin II-containing phycobilisome. I. Organization and sequence of the gene cluster encoding the major phycbiliprotein rod components in the genome of marine. Synechococcus SP Wh8020 J Biol Chem 1993 268 1226 1235 8419325
  83. Wilson KM Morrison IE Smith PR Fernandez N Cherry RJ Single particle tracking of cell-surface HLA-DR molecules using R-phycoerythrin labeled monoclonal antibodies and fluorescence digital imaging J Cell Sci 1996 109 2101 2109 8856506
  84. Wu S-H Lagarias JC Defining the bilin lyase domain: lessons from the extended phytochrome superfamily Biochemistry 2000 39 13487 13495 11063585
  85. Zabulon G Richaud C Guidi-Rontani C Thomas J-C NblA gene expression in synechocystis PCC 6803 strains lacking DspA (Hik33) and a NblR-like protein Curr Microbiol 2007 54 36 41 17171466
  86. Zhou J Gasparich GE Stirewalt VL de Lorimier R Bryant DA The cpcE and cpcF genes of Synechococcus sp. PCC 7002. Construction and phenotypic characterization of interposon mutants J Biol Chem 1992 267 16138 16145 1644801
  87. Zhao KH Wu D Wang L Zhou M Storf M Bubenzer C Characterization of phycoviolobilin phycoerythrocyanin- α84-cystein-lyase-(isomerizing) from Mastigocladus laminosus Eur J Biochem 2002 269 4542 4550 12230566
  88. Zhao KH Ran Y Li M Sun Y-N Zhou M Storf M Photochromic biliproteins from the cyanobacterium Anabaena sp. PCC 7120. lyase activities, chromophore exchange and photochromism in phytochrome and phycoerythrocyanin Biochemistry 2004a 43 11576 11588 15350144
  89. Zhao KH Zhu JP Song B Zhou M Storf M Böhm S Non-enzymatic chromophore attachment in biliproteins: conformational control by the detergent Triton X-100 Biochim Biophys Acta 2004b 1657 131 145 15238270
  90. Zhao KH Su P Böhm S Song B Zhou M Bubenzer C Scheer H Reconstitution of phycobilisome core-membrane linker, Lcm, by autocatalytic chromophore binding to ApcE Biochim Biophys Acta 2005a 1706 81 87 15620367
  91. Zhao KH Wu D Zhou M Zhang L Böhm S Bubenzer C Scheer H Amino acid residues associated with enzymatic activity of the isomerizing phycoviolobilin-lyase PecE/F Biochemistry 2005b 44 8126 8137 15924432
  92. Zhao K-H Wu D Zhang L Zhou M Böhm S Bubenzer C Scheer H Chromophore attachment in phycocyanin: functional amino acids of phycocyanobilin: α-phycocyanin lyase and evidence for chromophore binding FEBS J 2006a 273 1262 1274 16519690
  93. Zhao KH Su P Li JA Tu JM Zhou M Bubenzer C Scheer H Chromophore attachment to phycobiliprotein β-subunits: phycocyanobilin: cysteine-β84 phycobiliprotein lyase activity of CpeS-like protein from Anabaena sp. PCC7120 J Biol Chem 2006b 281 8573 8581 16452471
  94. Zhao KH Su P Tu JM Wang X Liu H Plöscher M Phycobilin: cystein-84 biliprotein lyase, a near-universal lyase for cysteine-84-binding sites in cyanobacterial phycobiliproteins Proc Natl Acad Sci USA 2007a 104 14300 14305 17726096 PMC1955460
  95. Zhao KH Zhang J Tu JM Böhm S Plöscher M Eichacker L Lyase activities of CpcS and CpcT-like proteins from Nostoc sp. PCC7120, and sequential reconstitution of binding sites of phycoerythrocyanin and phycocyanin β-subunits J Biol Chem 2007b 282 34093 34103 17895251

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Authors
Scheer, H., & Zhao, K. ‐.
Affiliations
  • Ludwig-Maximilians-Universität München (DE)
  • Huazhong University of Science and Technology (CN)
Corresponding author
Zhao, K.‐H.
ORCID
Venue
Molecular Microbiology
Publisher
Wiley
Published
2008-03-23
Volume
68
Issue
2
Pages
263-276
ISSN
  • 0950-382X (ISSN-L)
  • 1365-2958
DOI
10.1111/j.1365-2958.2008.06160.x
PMC
PMC2327270
OpenAlex
W2128785980
Cited by
198
References
1
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FWCI
0.98
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Molecular Microbiology (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft (SFB 533)
  • National Natural Science Foundation of China (30670489)
  • Program for New Century Excellent Talents in University
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
  • Physical Sciences › Materials Science › Materials Chemistry › Porphyrin and Phthalocyanine Chemistry
Keywords
chromophore attachment, bilins, phycobiliproteins, phycocyanin, phycocyanobilin, cyanobacteria, red algae, protein folding, fluorescent labeling
MeSH terms
Cyanobacteria, Rhodophyta, Bacterial Proteins, Protein Processing, Post-Translational, Phycobiliproteins

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