The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) σ factor protein family
Open accessAbstract
Summary: The ability of a bacterial cell to monitor and adaptively respond to its environment is crucial for survival. After one‐ and two‐component systems, extracytoplasmic function (ECF) σ factors – the largest group of alternative σ factors – represent the third fundamental mechanism of bacterial signal transduction, with about six such regulators on average per bacterial genome. Together with their cognate anti‐σ factors, they represent a highly modular design that primarily facilitates transmembrane signal transduction. A comprehensive analysis of the ECF σ factor protein family identified more than 40 distinct major groups of ECF σ factors. The functional relevance of this classification is supported by the sequence similarity and domain architecture of cognate anti‐σ factors, genomic context conservation, and potential target promoter motifs. Moreover, this phylogenetic analysis revealed unique features indicating novel mechanisms of ECF‐mediated signal transduction. This classification, together with the web tool ECF finder and the information stored in the Microbial Signal Transduction (MiST) database, provides a comprehensive resource for the analysis of ECF σ factor‐dependent gene regulation.
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TonB-dependent transporters: regulation, structure, and function
Noinaj, N., Guillier, M., Barnard, & Buchanan, S. K. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134247 · Cited by 989
Cell-surface signaling in Pseudomonas: stress responses, iron transport, and pathogenicity
Llamas, M. A., Imperi, F., Visca, P., & Lamont, I. L. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12078 · Cited by 176
Metadata
- Authors
- Staroń, A., Sofia, H. J., Dietrich, S., Ulrich, L. E., Liesegang, H., & Mascher, T.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2009-10-22
- Volume
- 74
- Issue
- 3
- Pages
- 557-581
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2168020930
- Cited by
- 375
- References
- 90
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Staroń, A., Sofia, H. J., Dietrich, S., Ulrich, L. E., Liesegang, H., & Mascher, T. (2009). The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) σ factor protein family. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2009.06870.x
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