The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
The association of metabolic syndrome with reflux esophagitis: a case-control study: Metabolic syndrome and reflux esophagitis
Open accessAbstract
BACKGROUND: Obesity has been associated with reflux esophagitis. However, the association of metabolic syndrome with reflux esophagitis remains unknown. METHODS: A case-control study of 372 subjects undergoing upper endoscopy during health checkups was conducted (182 patients with reflux esophagitis vs 190 age and gender-matched controls). We further measured their height, weight, waist circumference, hip circumference, blood pressure, triglyceride, high-density lipoprotein, and fasting blood glucose. Multivariable linear regression analysis was used to identify the independent risk factors associated with the presence of reflux esophagitis. KEY RESULTS: Reflux esophagitis cases showed higher mean waist circumference (81.37 ± 0.68 vs 79.36 ± 0.70, P < 0.05), waist hip ratio (0.86 ± 0.01 vs 0.84 ± 0.01, P < 0.05) and fasting blood glucose (5.59 ± 0.10 vs 5.32 ± 0.08, P < 0.05) than those in controls. When adjusted for gender and age, multivariate analysis demonstrated that there was a positive dose-response relationship between reflux esophagitis and waist hip ratio (men: OR 3.41, 95% CI 1.52-7.62, women: OR 3.37, 95% CI 1.61-7.06), triglyceride (OR 2.07, 95% CI 1.12-3.82), fasting blood glucose (OR 1.81, 95% CI 1.12-2.94), and metabolic syndrome (OR 2.01, 95% CI 1.15-3.50), there was an inverse dose-response relationship between reflux esophagitis and high-density lipoprotein for men (OR 0.36, 95% CI 0.15-0.85). CONCLUSIONS & INFERENCES: High waist hip ratio, triglyceride, fasting blood glucose, and metabolic syndrome were associated with increased risk factors for reflux esophagitis while high high-density lipoprotein for men correlated with a reduced risk of reflux esophagitis.
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“Moreover many metabolic disorders and diet-related chronic diseases appear to play key roles in the pathogenesis of GERD and non-erosive reflux disease [17], [20], [21].”
From Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis (2014) · cites this paper as [21]
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Cited by
Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis
Zayachkivska, O., Havryluk, O., Hrycevych, N., Bula, N., Grushka, O., & Wallace, J. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110688 · Cited by 34
“These concerns highlight the importance of better understanding the pathogenesis of GERD and identifying effective means of preventing and treating this disorder [5,21].”
Background
Metadata
- Authors
- Wu, P., Ma, L., Dai, G. X., Chen, Y., Tong, Y. L., Wang, C., Yao, L. W., Jiang, Y. X., Xu, S. C., & Ai, Z. S.
- Affiliations
- Tongji University (CN)
- Corresponding author
- Ma, L.
- Tong, Y. L.
- Xu, S. C.
- Ai, Z. S.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2011-09-13
- Volume
- 23
- Issue
- 11
- Pages
- 989-994
- ISSN
- 1350-1925 (ISSN-L)
- OpenAlex
- W1592528448
- Cited by
- 32
- References
- 36
- Citations by year
- 2026: 1 · 2024: 8 · 2023: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2014: 1 · 2013: 6 · 2012: 1
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1449 d)
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science and Technology Commission of Shanghai Municipality (10411968100)
- Tongji University
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
- Keywords
- metabolic syndrome, reflux esophagitis, waist-to-hip ratio, waist circumference, triglycerides, fasting blood glucose, high-density lipoprotein, obesity, risk factors, dose-response relationship
- MeSH terms
- Adult, Blood Glucose, Esophagitis, Peptic, Female, Humans, Lipoproteins, HDL, Male, Middle Aged, Obesity, Risk Factors, Triglycerides, Case-Control Studies, Metabolic Syndrome, Waist-Hip Ratio, Young Adult
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- The paper
- Wu, P., Ma, L., Dai, G. X., Chen, Y., Tong, Y. L., Wang, C., Yao, L. W., Jiang, Y. X., Xu, S. C., & Ai, Z. S. (2011). The association of metabolic syndrome with reflux esophagitis: a case-control study: Metabolic syndrome and reflux esophagitis. Neurogastroenterology & Motility. https://doi.org/10.1111/j.1365-2982.2011.01786.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
