The impact of argyrophilic grain disease on the development of dementia and its relationship to concurrent Alzheimer's disease‐related pathology
Abstract
Argyrophilic grain disease (AGD) constitutes a neurodegenerative disorder that occurs in the brains of the elderly and affects 5% of all patients with dementia. Tau protein-containing lesions known as argyrophilic grains and located predominantly in limbic regions of the brain characterize this disease. Dementia is encountered in only a subset of cases that display the morphological pattern of AGD. The aim of this study is to determine the role of concurrent Alzheimer's disease (AD)-related pathology for the development of dementia in AGD patients. A total of 204 post-mortem brains from 30 demented and 49 nondemented AGD patients, 39 AD patients, and from 86 nondemented controls without AGD were staged for AD-related neurofibrillary tangles (NFTs) as well as amyloid beta-protein (Abeta) deposition. To identify differences in AD-related pathology between demented and nondemented AGD cases, and to differentiate the pattern of AD-related changes in demented and nondemented AGD cases from that seen in AD and nondemented controls, we statistically compared the stages of Abeta and NFT distribution among these groups. Using a logistic regression model, we showed that AGD has a significant effect on the development of dementia beyond that attributable to AD-related pathology (P < 0.005). Demented AGD cases showed lower stages of AD-related pathology than did pure AD cases but higher stages than nondemented AGD patients. AGD associated dementia was seen in the presence of NFT (Braak)-stages II-IV and Abeta-phases 2-3, whereas those stages were not associated with dementia in the absence of AGD. In conclusion, AGD is a clinically relevant neurodegenerative entity that significantly contributes to the development of dementia by lowering the threshold for cognitive deficits in the presence of moderate amounts of AD-related pathology.
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Argyrophilic grain disease is more frequently observed in Alzheimer's disease than the general population and lowers the pathological threshold for clinical dementia.
“Argyrophilic grain disease is not only more frequently observed in Alzheimer’s disease than the general population, but it also lowers the pathological threshold for the presentation of clinical dementia [140].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [140]
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Self-citationNeurodegeneration in Normal Brain Aging and Disease
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Self-citationGender and age modify the association between APOE and AD-related neuropathology
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The neuropathological diagnosis of Alzheimer's disease
DeTure, M. A., & Dickson, D. W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0333-5 · Cited by 3,329 · see citing works
“lowers the pathological threshold for the presentation of clinical dementia [140].”
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Acetylated Tau Neuropathology in Sporadic and Hereditary Tauopathies
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Self-citationNeuropathological comorbidity associated with argyrophilic grain disease
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- Authors
- Thal, D. R., Schultz, C., Botez, G., Del Tredici, K., Mrak, R. E., Griffin, W. S. T., Wiestler, O. D., Braak, H., & Ghebremedhin, E.
- Affiliations
- University of Bonn (DE)
- Goethe University Frankfurt (DE)
- University of Arkansas for Medical Sciences (US)
- Corresponding author
- Thal, D. R.
- Venue
- Neuropathology and Applied Neurobiology
- Publisher
- Wiley
- Published
- 2005-01-24
- Volume
- 31
- Issue
- 3
- Pages
- 270-279
- ISSN
- 0305-1846 (ISSN-L)
- 1365-2990
- OpenAlex
- W1990107252
- Cited by
- 69
- References
- 6
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropathology and Applied Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Institute on Aging (AG 12411, P01AG012411)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- argyrophilic grain disease, dementia, Alzheimer's disease, neurofibrillary tangles, amyloid-beta deposition, Braak staging, argyrophilic grains, tau pathology, limbic system, postmortem brain, neurodegeneration
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Inclusion Bodies, Female, Humans, Male, Middle Aged, Logistic Models, Amyloid beta-Peptides, Neurofibrillary Tangles, Neurodegenerative Diseases
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