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Defective protective capacity of W/Wv mice against Strongyloides vatti infection and its reconstitution with bone marrow cells
Abstract
Summary The susceptibility of congenitally anemic, and mast cell deficient W/Wv mice to infection with Strongyloides ratti was examined. After a primary infection, W/Wv mice showed greater and more persistent peak larval counts than did normal littermates. Worm expulsion was also slower in W/Wv mice than in +/+ mice. Furthermore, difference in susceptibility was expressed as early as 24 h after infection, suggesting not only that protective mechanisms of the gut but also of the connective tissue were defective in W/Wv mice. Reconstitution with bone marrow or spleen cells from +/+ mice was effective in restoring the protective response in W/Wv mice, whereas thymocytes or mesenteric lymph nodes had no effect. Both connective tissue and mucosal mast cells were repaired in W/Wv mice after marrow reconstitution and infection. Since relatively long incubation period was required for the expression of such reconstituting activities, bone marrow cells seem to contain precursor cells of the effector and/or regulator cells.
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“Abnormalities in host responses to certain parasites have been observed in mice that genetically lack IgE [27, 28], mast cells [29–33], or basophils [28, 33] but such studies generally have not included an analysis of the effects of those deficiencies on the overall survival or reproductive success of the infected hosts.”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [29]
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Mast cells and IgE in defense against venoms: Possible “good side” of allergy?
Galli, S. J., Starkl, P., Marichal, T., & Tsai, M. (2016) · Allergology International · doi:10.1016/j.alit.2015.09.002 · Cited by 73
Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy
Galli, S. J., Metz, M., Starkl, P., Marichal, T., & Tsai, M. (2020) · Allergo Journal International · doi:10.1007/s40629-020-00118-6 · Cited by 57
Metadata
- Authors
- NAWA, Y., KIYOTA, M., KORENAGA, M., & KOTANI, M.
- Venue
- Parasite Immunology
- Publisher
- Wiley
- Published
- 1985-07
- Volume
- 7
- Issue
- 4
- Pages
- 429-438
- ISSN
- 0141-9838
- 1365-3024
- Cited by
- 74
- References
- 0
- Language
- en
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- NAWA, Y., KIYOTA, M., KORENAGA, M., & KOTANI, M. (1985). Defective protective capacity of W/Wv mice against Strongyloides vatti infection and its reconstitution with bone marrow cells. Parasite Immunology. https://doi.org/10.1111/j.1365-3024.1985.tb00088.x
