The Treg/Th17 Imbalance in Patients with Idiopathic Dilated Cardiomyopathy
Abstract
To assess whether Treg/Th17 balance was broken in patients with idiopathic dilated cardiomyopathy (DCM). We studied 25 patients who were diagnosed as idiopathic DCM (18 men and seven women, mean age 35.6 +/- 5.2) and 25 normal persons (18 men and seven women, mean age 33.8 +/- 4.9). Then, we detected Treg/Th17 functions on different levels including cell frequencies, related cytokine secretion and key transcription factors in patients with idiopathic DCM and controls. The results demonstrated that patients with idiopathic DCM revealed significant increase in peripheral Th17 number, Th17-related cytokines (IL-17, IL-6, IL-23) and transcription factor (RORgammat) levels and obvious decrease in Treg number, Treg-related cytokines (TGF-beta1 and IL-10) and transcription factor (Foxp3) levels when compared to normal persons. Results indicated that Treg/Th17 functional imbalance existed in patients with idiopathic DCM, suggesting a potential role for Treg/Th17 imbalance in the development of idiopathic DCM.
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Recent studies implemented pathogenic T cells as potential diagnostic or therapeutic targets for autoimmune myocarditis including ICI myocarditis, demonstrating promising outcomes at both clinical and preclinical levels.
“Recent studies implemented pathogenic T cells as potential diagnostic or therapeutic targets for autoimmune myocarditis including ICI myocarditis, demonstrating promising outcomes at both clinical and preclinical levels. 51,64,238,254,260,311,312”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [311]
In patients with myocarditis or idiopathic DCM who tested negative for specific viruses, circulating Th17 cells specific for cardiac myosin in the blood have been reported, along with a reduced number of regulatory T cells.
“In patients with myocarditis or idiopathic DCM who tested negative for specific viruses, the presence of circulating Th17 cells specific for cardiac myosin in the blood has been reported, along with a reduced number of regulatory T cells. 64,238,311”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [311]
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Baba, A., Yoshikawa, T., & Ogawa, S. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02075-2 · Cited by 92 · see citing works
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Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51 · see citing works
Fritsch, P., Craddock, T. J., del Rosario, R. M., Rice, M. A., Smylie, A., Folcik, V. A., de Vries, G., Fletcher, M. A., Klimas, N. G., & Broderick, G. (2013) · Systems Biomedicine · doi:10.4161/sysb.28948 · Cited by 16 · see citing works
- Authors
- Li, J., Wang, L., Wang, S., Zhu, H., Ye, P., Xie, A., Shen, B., Liu, C., Guo, C., Fu, Q., Zhang, K., & Xia, J.
- Affiliations
- Wuhan Union Hospital (CN)
- Corresponding author
- Xia, J.
- Venue
- Scandinavian Journal of Immunology
- Publisher
- Wiley
- Published
- 2010-04
- Volume
- 71
- Issue
- 4
- Pages
- 298-303
- ISSN
- 0300-9475 (ISSN-L)
- 1365-3083
- OpenAlex
- W2024554599
- Cited by
- 50
- References
- 2
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 3 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 1
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Keywords
- idiopathic dilated cardiomyopathy, regulatory T cells, Th17 cells, Th17/Treg balance, IL-17, IL-23, interleukin-6, TGF-β1, IL-10, RORγ, Foxp3, cytokines, transcription factors
- MeSH terms
- Adult, Cardiomyopathy, Dilated, Cell Separation, Female, Flow Cytometry, Humans, Male, T-Lymphocyte Subsets, Cytokines, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-17, T-Lymphocytes, Regulatory, Forkhead Transcription Factors, Nuclear Receptor Subfamily 1, Group F, Member 3
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