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The Arabidopsis FLC protein interacts directly in vivo with SOC1 and FT chromatin and is part of a high‐molecular‐weight protein complex
Open accessAbstract
Summary: The Arabidopsis Flowering Locus C (FLC) protein is a repressor of flowering regulated by genes in the autonomous and vernalization pathways. Previous genetic and transgenic data have suggested that FLC acts by repressing expression of the floral integrator genes SOC1 and FT . We have taken an in vivo approach to determine whether the FLC protein interacts directly with potential DNA targets. Using chromatin immunoprecipitation, we have shown that FLC binds to a region of the first intron of FT that contains a putative CArG box, and have confirmed that FLC binds to a CArG box in the promoter of the SOC1 gene. MADS box proteins are thought to bind their DNA targets as dimers or higher‐order multimers. We have shown that FLC is a component of a multimeric protein complex in vivo and that more than one FLC polypeptides can be present in the complex.
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Citations
Cited by
The genetic basis of flowering responses to seasonal cues
Andrés, F., & Coupland, G. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3291 · Cited by 1,538
Seasonal and developmental timing of flowering
Amasino, R. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04148.x · Cited by 894
Metadata
- Authors
- Helliwell, C. A., Wood, C. C., Robertson, M., James Peacock, W., & Dennis, E. S.
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2006-03-21
- Volume
- 46
- Issue
- 2
- Pages
- 183-192
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W1993928608
- Cited by
- 594
- References
- 0
- FWCI
- 30.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The Arabidopsis FLC protein interacts directly in vivo with SOC1 and FT chromatin and is part of a high‐molecular‐weight protein complex. https://app.cochat.ai/papers/10.1111/j.1365-313x.2006.02686.x
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- Helliwell, C. A., Wood, C. C., Robertson, M., James Peacock, W., & Dennis, E. S. (2006). The Arabidopsis FLC protein interacts directly in vivo with SOC1 and FT chromatin and is part of a high‐molecular‐weight protein complex. The Plant Journal. https://doi.org/10.1111/j.1365-313x.2006.02686.x
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