The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
A protocol for oral desensitization in children with IgE‐mediated cow's milk allergy
Abstract
Objectives: To desensitize children with severe immunoglobulin (Ig)E‐mediated cow's milk allergy in a period of 6 months by introducing increasing daily doses of cow's milk (CM) in order to enable the child to assume 200 ml of CM daily, or to induce tolerance of the highest possible CM dose. Study design: Twenty‐one children at least 6 years old with severe IgE‐mediated CM allergy were admitted to the study. A convincing history of IgE‐mediated CM allergy or a positive double‐blind placebo‐controlled food challenge with CM confirmed the diagnosis. Oral desensitization was performed with increasing doses starting from 0.06 mg of CM proteins. Results: Overall, 15 of 21 children (71.4%) achieved the daily intake of 200 ml during a 6‐month period; three of 21 children (14.3%) tolerated 40–80 ml/day of undiluted CM; three of 21 children (14.3%) failed the desensitization because they presented allergic symptoms after ingesting minimal amounts of diluted CM. Conclusions: We successfully desensitized 15 of 21 children with severe IgE‐mediated CM allergy in a period of 6 months. We stress the importance of the partial outcome in those three of 21 children who could not reach the maximum amount of 200 ml/day of whole CM, but were able to tolerate 40–80 ml/day of CM. In this way we dramatically reduced the risk of severe reactions after accidental or unnoticed introduction of low quantities of CM. We do not propose generalizing this method beyond trained staff.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis
Chen, Y., Kuchroo, V. K., Inobe, J.-I., Hafler, D. A., & Weiner, H. L. (1994) · Science · doi:10.1126/science.7520605 · Cited by 1,973
Johansson, S. G. O., Hourihane, J. O., Bousquet, J., Bruijnzeel-Koomen, C., Dreborg, S., Haahtela, T., Kowalski, M. L., Mygind, N., Ring, J., van Cauwenberge, P., et al. (2001) · Allergy · doi:10.1034/j.1398-9995.2001.t01-1-00001.x · Cited by 1,723
Sampson, H. A., & Ho, D. G. (1997) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(97)70133-7 · Cited by 1,055
Food allergy. Part 1: Immunopathogenesis and clinical disorders
Sampson, H. A. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70411-2 · Cited by 816
Peripheral deletion of antigen-reactive T cells in oral tolerance
Chen, Y., Inobe, J.-I., Marks, R., Gonnella, P., Kuchroo, V. K., & Weiner, H. L. (1995) · Nature · doi:10.1038/376177a0 · Cited by 783
Bock, S. A. (1987) · Pediatrics · doi:10.1542/peds.79.5.683 · Cited by 733
Oral tolerance: immune mechanisms and treatment of autoimmune diseases
Weiner, H. L. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01053-0 · Cited by 731
Høst, A., & Halken, S. (1990) · Allergy · doi:10.1111/j.1398-9995.1990.tb00944.x · Cited by 656
Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.
Friedman, A., & Weiner, H. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6688 · Cited by 635
Bruijnzeel‐Koomen, C., Ortolani, C., Aas, K., Bindslev‐Jensen, C., Björkstén, B., Moneret‐Vautrin, D., & Wüthrich, B. (1995) · Allergy · doi:10.1111/j.1398-9995.1995.tb02579.x · Cited by 557
Cited by
Staden, U., Rolinck‐Werninghaus, C., Brewe, F., Wahn, U., Niggemann, B., & Beyer, K. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01501.x · Cited by 466
Egg oral immunotherapy in nonanaphylactic children with egg allergy
Buchanan, A. D., Green, T. D., Jones, S. M., Scurlock, A. M., Christie, L., Althage, K. A., Steele, P. H., Pons, L., Helm, R. M., Lee, L. A., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.09.016 · Cited by 400
Peanut allergy: Emerging concepts and approaches for an apparent epidemic
Sicherer, S. H., & Sampson, H. A. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.07.015 · Cited by 337
Fleischer, D. M., Burks, A. W., Vickery, B. P., Scurlock, A. M., Wood, R. A., Jones, S. M., Sicherer, S. H., Liu, A. H., Stablein, D., Henning, A. K., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.11.011 · Cited by 309
Schneider, L. C., Rachid, R., LeBovidge, J., Blood, E., Mittal, M., & Umetsu, D. T. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.09.046 · Cited by 300
Metadata
- Authors
- Meglio, P., Bartone, E., Plantamura, M., Arabito, E., & Giampietro, P. G.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2004-08-02
- Volume
- 59
- Issue
- 9
- Pages
- 980-987
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W1976771675
- Cited by
- 372
- References
- 31
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A protocol for oral desensitization in children with IgE‐mediated cow's milk allergy. https://app.cochat.ai/papers/10.1111/j.1398-9995.2004.00542.x
- The paper
- Meglio, P., Bartone, E., Plantamura, M., Arabito, E., & Giampietro, P. G. (2004). A protocol for oral desensitization in children with IgE‐mediated cow's milk allergy. Allergy. https://doi.org/10.1111/j.1398-9995.2004.00542.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
