New topics in bradykinin research
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To cite this article: Maurer M, Bader M, Bas M, Bossi F, Cicardi M, Cugno M, Howarth P, Kaplan A, Kojda G, Leeb‐Lundberg F, Lötvall J, Magerl M. New topics in bradykinin research.Allergy2011;66: 1397–1406. Abstract Bradykinin has been implicated to contribute to allergic inflammation and the pathogenesis of allergic conditions. It binds to endothelial B1and B2receptors and exerts potent pharmacological and physiological effects, notably, decreased blood pressure, increased vascular permeability and the promotion of classical symptoms of inflammation such as vasodilation, hyperthermia, oedema and pain. Towards potential clinical benefit, bradykinin has also been shown to exert potent antithrombogenic, antiproliferative and antifibrogenic effects. The development of pharmacologically active substances, such as bradykinin receptor blockers, opens up new therapeutic options that require further research into bradykinin. This review presents current understanding surrounding the role of bradykinin in nonallergic angioedema and other conditions seen by allergists and emergency physicians, and its potential role as a therapeutic target.
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Captopril usage improved accumulation of paclitaxel-loaded nanoparticles in U87 glioma xenograft tumors.
“Captopril usage has improved the accumulation of paclitaxel-loaded nanoparticles in U87 glioma xenograft tumors [40,41,42].”
From Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis (2023) · cites this paper as [41]
The Pharmacological targeting of the kallikrein-kinin system section says B1 receptor antagonists increase glioma permeability and speculates that this could allow greater entry of cytostatic agents. It does not report captopril use or improved accumulation of paclitaxel-loaded nanoparticles in U87 xenografts. (LLM, conf=0.82)
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References 84 · Cited by 176
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- Authors
- Maurer, M., Bader, M., Bas, M., Bossi, F., Cicardi, M., Cugno, M., Howarth, P., Kaplan, A., Kojda, G., Leeb‐Lundberg, F., Lötvall, J., & Magerl, M.
- Affiliations
- Stiftung Charité (DE)
- University of Trieste (IT)
- University of Milan (IT)
- University of Southampton (GB)
- Medical University of South Carolina (US)
- Düsseldorf University Hospital (DE)
- University of Gothenburg (SE)
- Corresponding author
- Maurer, M.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2011-08-22
- Volume
- 66
- Issue
- 11
- Pages
- 1397-1406
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W1942364642
- Cited by
- 176
- References
- 84
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 9 · 2023: 12 · 2022: 11 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 11 · 2017: 10 · 2016: 10 · 2015: 17 · 2014: 22 · 2013: 22 · 2012: 9
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Allergy (publishedVersion)
- PubMed (publishedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Funders
- Shire Human Genetic Therapies
- Topics
- Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pineapple and bromelain studies
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Keywords
- bradykinin, bradykinin B1 receptor, bradykinin B2 receptor, allergic inflammation, bradykinin receptor antagonists, antifibrotic effect, vascular permeability, therapeutic target
- MeSH terms
- Angioedema, Animals, Bradykinin, Humans, Vasodilator Agents, Biomedical Research, Complement C1 Inhibitor Protein, Mice
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