Leptin for type 1 diabetes: coming onto stage to be (or not?)
Open accessAbstract
The discovery of the adipocyte hormone leptin completely changed our view of energy metabolism. In addition, the discovery of leptin rapidly progressed to clinical development. After a decade of clinical studies, leptin appears not to be the magic bullet therapy for obesity; however, it has a robust role in rare human conditions characterized by its deficiency. Recent exciting work from the Unger laboratory suggests that leptin therapy may also have a potential role for the treatment of Type 1 diabetes. In this review we discuss the positive evidence why such an approach is worthwhile. In order to achieve this broad goal, we reviewed available literature and provided our interpretation of the evidence presented in the original research papers. The potential cautionary aspects of this novel approach will be discussed in an accompanying article.
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Leptin might benefit type 1 diabetes therapy via its ability to reverse a catabolic state through suppression of hyperglucagonaemia.
“Leptin, the adipocyte hormone, might also benefit type 1 diabetes therapy via its ability to reverse a catabolic state through suppression of hypergluca-gonaemia.103”
From Type 1 diabetes (2014) · cites this paper as [103]
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Leptin-Replacement Therapy for Lipodystrophy
Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012437 · Cited by 1,247 · cited 1× · see citing works
“Leptin therapy leads to a reduction in food intake in non-obese humans such as women with hypothalamic amenorrhea (13) and in patients with lipodystrophy (14) as well as a few obese humans with mutations in the leptin gene (15).”
BackgroundSelf-citationLeptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038 · see citing works
Recombinant human leptin in women with hypothalamic amenorrhea
Welt, C. K., Chan, J. L., Bullen, J., Murphy, R., Smith, P., DePaoli, A. M., Karalis, A., & Mantzoros, C. S. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040388 · Cited by 908 · see citing works
Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice
Lee, Y., Wang, M.-Y., Du, X. Q., Charron, M. J., & Unger, R. H. (2011) · Diabetes · doi:10.2337/db10-0426 · Cited by 327 · see citing works
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
Asilmaz, E., Cohen, P., Miyazaki, M., Dobrzyn, P., Ueki, K., Fayzikhodjaeva, G., Soukas, A. A., Kahn, C. R., Ntambi, J. M., Socci, N. D., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419511 · Cited by 210 · see citing works
Cochran, E., Young, J. R., Sebring, N., DePaoli, A., Oral, E. A., & Gorden, P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031952 · Cited by 83 · see citing works
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Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,713 · see citing works
- Authors
- Oral, E. A.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Oral, Elif A
- ORCID
- Oral, Elif A
- Venue
- Pediatric Diabetes
- Publisher
- Hindawi Limited
- Published
- 2011-09-14
- Volume
- 13
- Issue
- 1
- Pages
- 68-73
- ISSN
- 1399-543X (ISSN-L)
- OpenAlex
- W1988161851
- Cited by
- 10
- References
- 6
- Citations by year
- 2023: 1 · 2019: 2 · 2015: 2 · 2013: 3 · 2012: 2
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pediatric Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK088114)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- leptin, type 1 diabetes, leptin therapy, leptin deficiency, obesity, energy metabolism, adipokines
- MeSH terms
- Animals, Diabetes Mellitus, Type 1, Energy Metabolism, Humans, Lipodystrophy, Mutation, Obesity, Receptor, Insulin, Adipocytes, Leptin, Lipid Metabolism
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