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Cited by 189

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Suicidal risk in bipolar I disorder patients and adherence to long‐term lithium treatment

Gonzalez‐Pinto, Ana, Mosquera, Fernando, Alonso, Marta, López, Purificación, Ramírez, Fernando, Vieta, Eduard, Baldessarini, Ross J·2006·Bipolar Disorders
DOI 10.1111/j.1399-5618.2006.00368.x
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Abstract

Objectives: Among the well‐established treatments for bipolar disorder (BPD), lithium continues to offer an unusually broad spectrum of benefits that may include reduction of suicidal risk. Methods: We examined the association of suicidal acts with adherence to long‐term lithium maintenance treatment and other potential risk factors in 72 BP I patients followed prospectively for up to 10 years at a Mood Disorders Research Center in Spain. Results: The observed rates of suicide were 0.143, and of attempts, 2.01%/year, with a 5.2‐fold (95% CI: 1.5–18.6) greater risk among patients consistently rated poorly versus highly adherent to lithium prophylaxis (11.4/2.2 acts/100 person‐years). Treatment non‐adherence was associated with substance abuse, being unmarried, being male, and having more hypomanic–manic illness and hospitalizations. Suicidal risk was higher with prior attempts, more depression and hospitalization, familial mood disorders, and being single and younger, as well as treatment non‐adherence, but with neither sex nor substance abuse. In multivariate analysis, suicidal risk was associated with previous suicidality > poor treatment adherence > more depressive episodes > younger age. Conclusions: The findings support growing evidence of lower risk of suicidal acts during closely monitored and highly adherent, long‐term treatment with lithium and indicate that treatment adherence is a potentially modifiable factor contributing to antisuicidal benefits.

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Metadata

Authors
Gonzalez‐Pinto, A., Mosquera, F., Alonso, M., López, P., Ramírez, F., Vieta, E., & Baldessarini, R. J.
Venue
Bipolar Disorders
Publisher
Wiley
Published
2006-10
Volume
8
Issue
5p2
Pages
618-624
ISSN
  • 1398-5647 (ISSN-L)
  • 1399-5618
DOI
10.1111/j.1399-5618.2006.00368.x
OpenAlex
W2116348238
Cited by
189
References
8
FWCI
7.67
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Suicidal risk in bipolar I disorder patients and adherence to long‐term lithium treatment. https://app.cochat.ai/papers/10.1111/j.1399-5618.2006.00368.x
The paper
Gonzalez‐Pinto, A., Mosquera, F., Alonso, M., López, P., Ramírez, F., Vieta, E., & Baldessarini, R. J. (2006). Suicidal risk in bipolar I disorder patients and adherence to long‐term lithium treatment. Bipolar Disorders. https://doi.org/10.1111/j.1399-5618.2006.00368.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.