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Isolation from Porcine‐Intestinal Wall of a Vasoactive Octacosapeptide Related to Secretin and to Glucagon
Abstract
A polypeptide composed of 28 amino acid residues has been isolated from porcine upper intestinal wall. In addition to exhibiting several biological activities which may be attributed to a relaxant effect on vascular and systemic smooth muscle it stimulates exocrine pancreatic secretion in a secretin‐like fashion, with an apparent efficiency, on a molar basis, of 5–10% of that of secretin and also gives rise to hyperglycaemia with about 30% of the efficiency of glucagon. Structurally it resembles secretin and glucagon in having a histidyl‐seryl sequence N‐terminally. Of the amino acid residues commonly occurring in mammalian proteins the residues of cysteine/cystine, glycine, proline and tryptophan are absent from it.
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Citations
Cited by
Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue
McDonald, T. J., Jörnvall, H., Nilsson, G., Vagne, M., Ghatei, M., Bloom, S. R., & Mutt, V. (1979) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(79)91614-0 · Cited by 874
Self-citationVasoactive intestinal polypeptide (VIP) in mouse and rat brain: An immunocytochemical study
Sims, K. B., Hoffman, D. L., Said, S. I., & Zimmerman, E. A. (1980) · Brain Research · doi:10.1016/0006-8993(80)90263-2 · Cited by 396
Self-citationCloning and Characterization of the Human Activity-dependent Neuroprotective Protein
Zamostiano, R., Pinhasov, A., Gelber, E., Steingart, R. A., Seroussi, E., Giladi, E., Bassan, M., Wollman, Y., Eyre, H. J., Mulley, J. C., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007416200 · Cited by 251
Stimulation of insulin and glucagon secretion by vasoactive intestinal peptide.
Schebalin, M., Said, S. I., & Makhlouf, G. M. (1977) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1977.232.2.e197 · Cited by 74
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Metadata
- Authors
- Said, S. I., & Mutt, V.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1972-07
- Volume
- 28
- Issue
- 2
- Pages
- 199-204
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W1976694824
- Cited by
- 526
- References
- 0
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Said, S. I., & Mutt, V. (1972). Isolation from Porcine‐Intestinal Wall of a Vasoactive Octacosapeptide Related to Secretin and to Glucagon. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1972.tb01903.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
