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Differences between the ATP/ADP Ratios in the Mitochondrial Matrix and in the Extramitochondrial Space
Open accessAbstract
The relationship between the ATP/ADP ratios inside and outside the mitochondria was studied using silicon‐layer centrifugation. As predicted from the properties of the adenine nucleotide translocation, the ATP/ADP ratio in the extramitochondrial space was found to be higher than in the mitochondria when in the state of respiratory control. Taking into account the content of inorganic phosphate, the phosphorylation potential in the mitochondria is calculated to be 2.3 kcal lower than in the medium. This difference between the internal and external ATP/ADP ratios is abolished if uncoupler is added, When there is also no Mg 2+ present in the medium, the internal ATP/ADP ratio may be even higher than the external ratio, provided that there was oligomycin added in order to inhibit ATP hydrolysis. It is shown that the ADP is transported against a gradient from the extramitochondrial space into the mitochondria. The discussion of a model suggests that the physiological role of the energy‐requiring transport of ADP into the mitochondria is to maintain a constant level of the ATP in the cytosol.
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Citations
Cited by
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Erecińska, M., & Wilson, D. F. (1982) · The Journal of Membrane Biology · doi:10.1007/bf01871584 · Cited by 437
SCHLEYER, M., SCHMIDT, B., & NEUPERT, W. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb06657.x · Cited by 295
Significance of skeletal muscle oxidative enzyme enhancement with endurance training.
Gollnick, P. D., & Saltin, B. (1982) · Clinical Physiology · doi:10.1111/j.1475-097x.1982.tb00001.x · Cited by 277
Mitochondrial contact sites: their role in energy metabolism and apoptosis
Brdiczka, D. G., Zorov, D. B., & Sheu, S.-S. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.09.007 · Cited by 150
A 20/20 view of ANT function in mitochondrial biology and necrotic cell death
Bround, M. J., Bers, D. M., & Molkentin, J. D. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.05.012 · Cited by 83
Metadata
- Authors
- Heldt, H. W., Klingenberg, M., & Milovancev, M.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1972-11
- Volume
- 30
- Issue
- 3
- Pages
- 434-440
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W2048892209
- Cited by
- 176
- References
- 0
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Heldt, H. W., Klingenberg, M., & Milovancev, M. (1972). Differences between the ATP/ADP Ratios in the Mitochondrial Matrix and in the Extramitochondrial Space. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1972.tb02115.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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