The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Fate of Protein‐Containing Liposomes Injected into Rats: An Approach to the Treatment of Storage Diseases
Open accessAbstract
[3 H]Amyloglucosidase and 131 I‐labelled albumin were entrapped into liposomes (lipid spherules) composed of phosphatidyl choline, cholesterol and dicetyl phosphate (7:2:1 molar ratio). 131 I‐labelled albumin was also entrapped in [3 H]cholesterol‐liposomes. Investigations on the fate in vivo following intravenous injection of such protein‐containing liposomes into rats, showed that the bulk of liposomal radioactivity is removed from the blood within minutes. There is no measurable leakage of entrapped 131 I‐labelled albumin while liposomes are in the circulation. Most of the removed liposomal radioactivity was recovered in the liver. Autoradiographic examination of the liver 3 min after injection of albumin‐containing [3 H]cholesterol‐liposomes suggests that hepatocytes and probably Kupffer cells are involved in the uptake of liposomes. It appears that liposomes enter this tissue intact but subsequently liposomal membranes and entrapped protein are catabolized. These catabolic processes are probably occurring in the liver lysosomes, as most of the liposomal radioactivity in this tissue was recovered in the mitochondrial‐lysosomal fraction. Liposomes appear to be promising as a vehicle for the administration of enzymes and possibly also drugs to patients with storage diseases.
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Citations
Cites
Lysosomes in biology and pathology
(1977) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(77)80214-9 · Cited by 1,968
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Reductive alkylation of amino groups in proteins
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Physical and Chemical Studies on Ceruloplasmin
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Phospholipid spherules (liposomes) as a model for biological membranes
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Brady, R. O., Kanfer, J. N., Bradley, R. M., & Shapiro, D. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105417 · Cited by 411
Enzyme entrapment in liposomes
Gregoriadis, G., Leathwood, P. D., & Ryman, B. E. (1971) · FEBS Letters · doi:10.1016/0014-5793(71)80109-6 · Cited by 331
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Cited by
De Duve, C., De Barsy, T., Poole, B., Trouet, A., Tulkens, P., & Van Hoof, F. (1974) · Biochemical Pharmacology · doi:10.1016/0006-2952(74)90174-9 · Cited by 1,901
Sterically stabilized liposomes
Woodle, M. C., & Lasic, D. D. (1992) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(92)90038-c · Cited by 954
Fendler, J. H., & Romero, A. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90481-7 · Cited by 657
Juliano, R. L., & Stamp, D. (1975) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(75)80433-5 · Cited by 522
Current status of pH-sensitive liposomes in drug delivery
Drummond, D. C., Zignani, M., & Leroux, J.-C. (2000) · Progress in Lipid Research · doi:10.1016/s0163-7827(00)00011-4 · Cited by 477
Metadata
- Authors
- Gregoriadis, G., & Ryman, B. E.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1972-01
- Volume
- 24
- Issue
- 3
- Pages
- 485-491
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W1868696300
- Cited by
- 345
- References
- 13
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
