The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Isolation of High‐Molecular‐Weight DNA from Mammalian Cells
Abstract
A preparative method for isolating high‐molecular‐weight DNA from animal cells is described. This method is based on the use of proteinase K, a powerful proteolytic enzyme with a broad action spectrum, which is very active in the presence of sodium dodecylsulfate and ethylene‐diamine tetraacetate. The DNA preparation is free of RNA, protein and degrading enzymes. The number‐average molecular weight of the native DNA is 190 × 10 6, whereas it is 90 × 10 6 for single‐stranded DNA, indicating that the DNA molecules do not contain single‐stranded nicks. The native DNA molecules range in molecular weight from 40 × 10 6 to more than 500 × 10 6.
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Citations
Cites
Burton, K. (1956) · Biochemical Journal · doi:10.1042/bj0620315 · Cited by 14,090
Cited by
A general method for isolation of high molecular weight DNA from eukaryotes
Blin, N., & Stafford, D. W. (1976) · Nucleic Acids Research · doi:10.1093/nar/3.9.2303 · Cited by 2,770
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene
Basler, K., Oesch, B., Scott, M., Westaway, D., Wälchli, M., Groth, D. F., McKinley, M. P., Prusiner, S. B., & Weissmann, C. (1986) · Cell · doi:10.1016/0092-8674(86)90662-8 · Cited by 835
Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.
Hozumi, N., & Tonegawa, S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.10.3628 · Cited by 759
Ellis, R. W., DeFeo, D., Shih, T. Y., Gonda, M. A., Young, H. A., Tsuchida, N., Lowy, D. R., & Scolnick, E. M. (1981) · Nature · doi:10.1038/292506a0 · Cited by 721
Tilly, J. L., & Tilly, K. I. (1995) · Endocrinology · doi:10.1210/en.136.1.242 · Cited by 357
Metadata
- Authors
- Gross‐Bellard, M., Oudet, P., & Chambon, P.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1973-07
- Volume
- 36
- Issue
- 1
- Pages
- 32-38
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W2142617031
- Cited by
- 1,666
- References
- 1
- FWCI
- 9.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gross‐Bellard, M., Oudet, P., & Chambon, P. (1973). Isolation of High‐Molecular‐Weight DNA from Mammalian Cells. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1973.tb02881.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
