The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid. A novel cyclic amino acid from halophilic phototrophic bacteria of the genus Ectothiorhodospira
Open accessAbstract
A novel cyclic amino acid was detected in and subsequently isolated from extremely halophilic species of the bacterial genus Ectothiorhodospira. The structure of this new compound was elucidated by a combination of nuclear magnetic resonance (NMR) techniques and mass spectrometry. 1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid is only accumulated within the cytoplasm under certain growth conditions and seems to serve an osmoregulatory function. There is no previous reference to this molecule in the chemical literature and we, therefore, propose to use the trivial name 'ectoine', due to its discovery in members of the bacterial genus Ectothiorhodospira. (formula: see text).
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Cites
Brown, A. D. (1976) · Bacteriological Reviews · doi:10.1128/br.40.4.803-846.1976 · Cited by 867
Organic Osmoregulatory Solutes in Cyanobacteria
MACKAY, M. A., NORTON, R. S., & BOROWITZKA, L. J. (1984) · Microbiology · doi:10.1099/00221287-130-9-2177 · Cited by 269
Carbohydrate Accumulation and Osmotic Stress in Cyanobacteria
Reed, R. H., Richardson, D. L., Warr, S. R. C., & Stewart, W. D. P. (1984) · Microbiology · doi:10.1099/00221287-130-1-1 · Cited by 252
ACCUMULATION OF METABOLITES BY HALOTOLERANT ALGAE AND ITS INDUSTRIAL POTENTIAL
Ben-Amotz, A., & Avron, M. (1983) · Annual Review of Microbiology · doi:10.1146/annurev.mi.37.100183.000523 · Cited by 236
Betaine is the main compatible solute of halophilic eubacteria
Imhoff, J. F., & Rodriguez-Valera, F. (1984) · Journal of Bacteriology · doi:10.1128/jb.160.1.478-479.1984 · Cited by 193
Imhoff, J. F., & Tr�per, H. G. (1977) · Archives of Microbiology · doi:10.1007/bf00410772 · Cited by 190
Galinski, E. A., & Trüper, H. G. (1982) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1982.tb08287.x · Cited by 182
Self-citationChapter IV Chemical Extraction Methods of Microbial Cells
Sutherland, I. W., & Wilkinson, J. F. (1971) · Methods in microbiology · doi:10.1016/s0580-9517(08)70642-1 · Cited by 109
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Extremolytes: natural compounds from extremophiles for versatile applications
Lentzen, G., & Schwarz, T. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0553-9 · Cited by 340
Schwibbert, K., Marin‐Sanguino, A., Bagyan, I., Heidrich, G., Lentzen, G., Seitz, H., Rampp, M., Schuster, S. C., Klenk, H., Pfeiffer, F., et al. (2011) · Environmental Microbiology · doi:10.1111/j.1462-2920.2010.02336.x · Cited by 274
Metadata
- Authors
- GALINSKI, E. A., PFEIFFER, H.-P., & TRUPER, H. G.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1985-05
- Volume
- 149
- Issue
- 1
- Pages
- 135-139
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W1580982499
- Cited by
- 425
- References
- 8
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: 1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid. A novel cyclic amino acid from halophilic phototrophic bacteria of the genus Ectothiorhodospira. https://app.cochat.ai/papers/10.1111/j.1432-1033.1985.tb08903.x
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- GALINSKI, E. A., PFEIFFER, H.-P., & TRUPER, H. G. (1985). 1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid. A novel cyclic amino acid from halophilic phototrophic bacteria of the genus Ectothiorhodospira. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1985.tb08903.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
