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Diversity of corrinoids in acetogenic bacteria: P‐Cresolylcobamide from Sporomusa ovata, 5‐methoxy‐6‐methylbenzimidazolylcobamide from Clostridium formicoaceticum and vitamin B12 from Acetobacterium woodii
Open accessAbstract
The Coβ‐cyanocobamides obtained by cyanide extractions from several acetogenic bacteria were structurally characterized by ultraviolet visible spectra, proton‐nuclear‐magnetic‐resonance spectra and fast‐atom‐bombardment mass spectra. p‐Cresolylcobamide was detected as a major corrinoid from Sporomusa ovata. This ‘complete’ corrinoid was isolated from an organism for the first time. Instead of the common Coα bases of the known and biologically active cobamides, p‐cresolylcobamide contained a glycosidically bound cresolyl function that was unable to coordinate to the cobalt of the corrin ring. An additional, previously unknown corrinoid from natural sources, Coα‐[α‐(5‐methoxy‐6‐methylbenzimidazolyl)]‐Coβ‐cyanocobamide, was isolated along with vitamin B 12 from Clostridium formicoaceticum. Both homoacetogenic eubacteria were grown on methanol and contained high amounts of corrinoids (> 950 nmol/g cell dry mass). Less corrinoid was isolated from Acetobacterium woodii and characterized as vitamin B 12.
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“Earlier gene‐based investigations of corrin biosynthesis evolution [80, 155, 156, 157] have missed the role of corrinoids in CoFeS and the acetyl‐CoA pathway, even though their function in ancient pathways has long been evident [7, 8, 48, 49].”
From Evidence for corrin biosynthesis in the last universal common ancestor (2025) · cites this paper as [8]
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Cited by
Sorted by citations
Evidence for corrin biosynthesis in the last universal common ancestor
Modjewski, L. D., Karavaeva, V., Mrnjavac, N., Knopp, M., Martin, W. F., & Sousa, F. L. (2025) · The FEBS Journal · doi:10.1111/febs.17367 · Cited by 15
“Other organisms employ different intermediates of lower ligand synthesis [39], and the lower ligands of coba-mides isolated from acetogens [7] and methanogens vary across species [8].”
Influential
Metadata
- Authors
- STUPPERICH, E., EISINGER, H. J., & KRÄUTLER, B.
- Affiliations
- Universität Ulm (DE)
- ETH Zurich (CH)
- Corresponding author
- STUPPERICH, Erhard
- ORCID
- KRÄUTLER, Bernhard
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1988-03
- Volume
- 172
- Issue
- 2
- Pages
- 459-464
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W1584316379
- Cited by
- 113
- References
- 0
- Citations by year
- 2025: 1 · 2024: 5 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 8
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- corrinoids, acetogenic bacteria, cobamide, Sporomusa ovata, vitamin B12, Acetobacterium woodii, homoacetogenic bacteria, methanol growth
- MeSH terms
- Bacteria, Anaerobic, Clostridium, Cobamides, Gram-Positive Bacteria, Magnetic Resonance Spectroscopy, Vitamin B 12, Corrinoids
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