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Computational Studies of the Regioselectivities of COMT-CatalyzedMeta-/Para-O Methylations of Luteolin and Quercetin

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No direct effect of the -521 C/T polymorphism in the human dopamine D4 receptor gene promoter on transcriptional activity

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Effect of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal function

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Chronic antipsychotics treatment regulates MAOA, MAOB and COMT gene expression in rat frontal cortex

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Breast Cancer Risk Reduction and Membrane-Bound Catechol O -Methyltransferase Genetic Polymorphisms

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Are catechol-O-methyltransferase gene polymorphisms genetic markers for pain sensitivity after all? – A review and meta-analysis

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Role of Catechol-O-Methyltransferase (COMT)-Dependent Processes in Parkinson’s Disease and L-DOPA Treatment

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Catechol-O-Methyltransferase Valine158Methionine Polymorphism Moderates Methylphenidate Effects on Oppositional Symptoms in Boys with Attention-Deficit/Hyperactivity Disorder

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Genetic Polymorphisms of Catechol- O -Methyltransferase Modify the Neurobehavioral Effects of Mercury in Children

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Inhibitors of Catechol-O-methyltransferase in the Treatment of Neurological Disorders

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Green Tea Extract Inhibition of Human Leiomyoma Cell Proliferation Is Mediated via Catechol-O-Methyltransferase

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Catechol-O-methyltransferase Val158Met polymorphism and altered COMT gene expression in the prefrontal cortex of suicide brains

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Catechol-O-methyltransferase (COMT) genotypes are associated with varying soluble, but not membrane-bound COMT protein in the human prefrontal cortex

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Importance of membrane‐bound catechol‐O‐methyltransferase in L‐DOPA metabolism: a pharmacokinetic study in two types ofComtgene modified mice

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Breed Differences in Genotype and Allele Frequency of Catechol O-Methyltransferase Gene polymorphic Regions in Dogs

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Methylation, Glucuronidation, and Sulfonation of Daphnetin in Human Hepatic Preparations In Vitro : Metabolic Profiling, Pathway Comparison, and Bioactivity Analysis

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Purification methods of mammalian catechol-O-methyltransferases

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Detoxication of Structurally Diverse Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones by Human Recombinant Catechol-O-methyltransferase (COMT) via O-Methylation of PAH Catechols

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Nuclear Localization of Catechol-O-Methyltransferase in Neoplastic and Nonneoplastic Mammary Epithelial Cells

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Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: the role of gender

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Assessment of O-methylated catecholamine levels in plasma and urine for diagnosis of autonomic disorders

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Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson’s disease

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Evaluation of MutS and Mut+ Pichia pastoris Strains for Membrane-Bound Catechol-O-Methyltransferase Biosynthesis

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Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children's internalizing symptoms and inhibitory control: Evidence for differential susceptibility

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Progesterone regulates catechol-O-methyl transferase gene expression in breast cancer cells: Distinct effect of progesterone receptor isoforms

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Identification, characterization, and ontogenic study of a catechol O-methyltransferase from zebrafish

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Catechol-O-Methyltransferase (COMT) Protein Expression and Activity after Dopaminergic and Noradrenergic Lesions of the Rat Brain

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Association of COMT and TPH-2 genes with DSM-5 based PTSD symptoms

Goenjian, A. K., Noble, E. P., Steinberg, A. M., Walling, D. P., Stepanyan, S. T., Dandekar, S., & Bailey, J. N. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.10.034 · Cited by 25

Diverse Facets of COMT: From a Plausible Predictive Marker to a Potential Drug Target for Schizophrenia

Gupta, M., Kaur, H., Jajodia, A., Jain, S., Satyamoorthy, K., Mukerji, M., Thirthalli, J., & Kukreti, R. (2011) · Current Molecular Medicine · doi:10.2174/156652411798062386 · Cited by 25

Polymorphisms of Catechol-O-Methyltransferase in Men with Renal Cell Cancer

Tanaka, Y., Hirata, H., Chen, Z., Kikuno, N., Kawamoto, K., Majid, S., Tokizane, T., Urakami, S., Shiina, H., Nakajima, K., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0605 · Cited by 24

The 108M Polymorph of Human CatecholO-Methyltransferase Is Prone to Deformation at Physiological Temperatures

Rutherford, K., Bennion, B. J., Parson, W. W., & Daggett, V. (2006) · Biochemistry · doi:10.1021/bi051988i · Cited by 23

Evaluation of genetic risk related to catechol-O-methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) activity in different diagnostic subgroups of temporomandibular disorder in Brazilian patients

Tesch, R. D. S., Bonato, L. L., Quinelato, V., Casado, P. L., Vieira, A. R., Granjeiro, J. M., & Goes, C. P. D. Q. F. (2019) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.ijom.2019.06.027 · Cited by 23

Haplotype analysis of the COMT‐ARVCF gene region in Israeli anorexia nervosa family trios

Michaelovsky, E., Frisch, A., Leor, S., Stein, D. J., Danziger, Y., Carel, C. A., Fennig, S., Mimouni, M., Klauck, S. M., Benner, A., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30230 · Cited by 23

A Hotspot of Inactivation: The A22S and V108M Polymorphisms Individually Destabilize the Active Site Structure of CatecholO-Methyltransferase

Rutherford, K., & Daggett, V. (2009) · Biochemistry · doi:10.1021/bi900174v · Cited by 23

The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: Findings from a large German case-control and family-based sample

Nieratschker, V., Frank, J., Mühleisen, T. W., Strohmaier, J., Wendland, J. R., Schumacher, J. H., Treutlein, J., Breuer, R., Jamra, R. A., Mattheisen, M., et al. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.06.018 · Cited by 22

Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia

Liao, S., Lin, S., Liu, C., Hsieh, M. H., Hwang, T., Liu, S., Guo, S., Hwu, H., & Chen, W. J. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2008.00467.x · Cited by 22

Impact of Catechol-O-Methyltransferase Val 158Met (rs4680) Polymorphism on Breast Cancer Susceptibility in Asian Population

Rai, V., Yadav, U., & Kumar, P. (2017) · Asian Pacific Journal of Cancer Prevention · doi:10.22034/apjcp.2017.18.5.1243 · Cited by 24

Genes of the dopaminergic system selectively modulate top-down but not bottom-up attention

Schneider, K. K., Schote, A. B., Meyer, J., & Frings, C. (2014) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-014-0320-9 · Cited by 21

Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain

Su, Y.-P., Depasquale, M. J., Liao, G., Buchler, I. P., Zhang, G., Byers, S., Carr, G. V., Barrow, J. C., & Wei, H. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173909 · Cited by 21

Val/Met Polymorphism of the COMT Gene Moderates the Association Between Job Strain and Early Atherosclerosis in Young Men

Hintsanen, M., Elovainio, M. J., Puttonen, S., Mika Kivimaki, B., Lehtimäki, T. J., Kähönen, M. A. P., Juonala, M., Rontu, R., Viikari, J. S. A., Raitakari, O. T., et al. (2008) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0b013e318165c7ec · Cited by 21

Associations between catechol-O-methyltransferase (COMT) genotypes at rs4818 and rs4680 and gene expression in human dorsolateral prefrontal cortex

Dean, B., Parkin, G. M., & Gibbons, A. S. (2020) · Experimental Brain Research · doi:10.1007/s00221-020-05730-0 · Cited by 20

Genetic Variants and Early Cigarette Smoking and Nicotine Dependence Phenotypes in Adolescents

O'Loughlin, J., Sylvestre, M.-P., Labbe, A., Low, N. C., Roy-Gagnon, M.-H., Dugas, E. N., Karp, I., & Engert, J. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115716 · Cited by 21

Novel, non-nitrocatechol catechol-O-methyltransferase inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility

Byers, S., Buchler, I. P., Depasquale, M. J., Rowley, H. L., Kulkarni, R. S., Pinder, L., Kolobova, A., Li, C., Au, V., Akuma, D., et al. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05566-0 · Cited by 21

Dynamic DNA methylation changes in the COMT gene promoter region in response to mental stress and its modulation by transcranial direct current stimulation

Wiegand, A., Blickle, A., Brückmann, C., Weller, S., Nieratschker, V., & Plewnia, C. (2021) · Biomolecules · doi:10.3390/biom11111726 · Cited by 19

Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability

Hatzimanolis, A., Vitoratou, S., Mandelli, L., Vaiopoulos, C., Nearchou, F., Stefanis, C. N., Serretti, A., & Stefanis, N. C. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.12.018 · Cited by 20

Cathechol-O-methyltransferase Val 158 Met polymorphism is associated with disruptive behavior disorders among children and adolescents with ADHD

Salatino‐Oliveira, A., Genro, J. P., Guimarães, A. P., Chazan, R., Zeni, C., Schmitz, M. D., Polanczyk, G. V., Roman, T., Rohde, L. A., & Hutz, M. H. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0766-2 · Cited by 18

Association of MB-COMT polymorphisms with schizophrenia-susceptibility and symptom severity in an African cohort

Wright, G. E. B., Niehaus, D. J. H., van der Merwe, L., Koen, L., Korkie, L., Kinnear, C. J., Drögemöller, B. I., & Warnich, L. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.06.006 · Cited by 18

Separation methods for catechol O-methyltransferase activity assay: physiological and pathophysiological relevance

Pihlavisto, P., & Reenilä, I. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00429-4 · Cited by 18

Effect of Catechol-O-Methyltransferase Genotype Polymorphism on Neurological and Psychiatric Disorders: Progressing Towards Personalized Medicine

Srivastava, K., Ochuba, O., Sandhu, J. K., Alkayyali, T., Ruo, S. W., Waqar, A., Jain, A. K., Joseph, C. G., & Poudel, S. (2021) · Cureus · doi:10.7759/cureus.18311 · Cited by 17

Methyltransferases

Lennard, L. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.00421-8 · Cited by 17

Structure of the Rat Catechol- O -Methyltransferase Gene: Separate Promoters Are Used to Produce mRNAs for Soluble and Membrane-Bound Forms of the Enzyme

Tenhunen, J., Salminen, M., Jalanko, A., UKKONEN, S., & Ulmanen, I. (1993) · DNA and Cell Biology · doi:10.1089/dna.1993.12.253 · Cited by 74

Production of rat soluble and membrane-bound catechol O-methyltransferase forms from bifunctional mRNAs

Tenhunen, J., & Ulmanen, I. (1993) · Biochemical Journal · doi:10.1042/bj2960595 · Cited by 59

Characterization of the Rat Catechol- O -Methyltransferase Gene Proximal Promoter: Identification of a Nuclear Protein–DNA Interaction That Contributes to the Tissue-Specific Regulation

Tenhunen, J. (1996) · DNA and Cell Biology · doi:10.1089/dna.1996.15.461 · Cited by 17

Expression of Functional Membrane‐Bound and Soluble Catechol‐O‐Methyltransferase in Escherichia coli and a Mammalian Cell Line

Malherbe, P., Bertocci, B., Caspers, P., Zürcher, G., & Prada, M. D. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10054.x · Cited by 45

Molecular cloning and characterization of rat liver catechol-O-methyltransferase

Salminen, M., Lundstrom, K. H., Tilgmann, C., Savolainen, R., Kalkkinen, N., & Ulmanen, I. (1990) · Gene · doi:10.1016/0378-1119(90)90231-f · Cited by 118