The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Two binding sites of inhibitors in NADH:ubiquinone oxidoreductase (complex I): Relationship of one site with the ubiquinone‐binding site of bacterial glucose:ubiquinone oxidoreductase
Open accessAbstract
The effect of ten naturally occurring and two synthetic inhibitors of NADH:ubiquinone oxidoreductase (complex I) of bovine heart, Neurospora crassa and Escherichia coli and glucose:ubiquinone oxidoreductase (glucose dehydrogenase) of Gluconobacter oxidans was investigated. These inhibitors could be divided into two classes with regard to their specifity and mode of action. Class I inhibitors, including the naturally occuring piericidin A, annonin VI, phenalamid A 2, aurachins A and B, thiangazole and the synthetic fenpyroximate, inhibit complex I from all three species in a partially competitive manner and glucose dehydrogenase in a competitive manner, both with regard to ubiquinone. Class II inhibitors including the naturally occuring rotenone, phenoxan, aureothin and the synthetic benzimidazole inhibit complex I from all species in an non‐competitive manner, but have no effect on the glucose dehydrogenase. Myxalamid PI could not be classified as above because it inhibits only the mitochondrial complex I and in a competitive manner. All inhibitors affect the electron‐transfer step from the high‐potential iron‐sulphur cluster to ubiquinone. Class I inhibitors appear to act directly at the ubiquinone‐catalytic site which is related in complex I and glucose dehydrogenase.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
THE MITOCHONDRIAL ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION SYSTEM
Hatefi, Y. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.005055 · Cited by 1,680
The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains
Walker, J. E. (1992) · Quarterly Reviews of Biophysics · doi:10.1017/s003358350000425x · Cited by 781
The respiratory‐chain NADH dehydrogenase (complex I) of mitochondria
WEISS, H., FRIEDRICH, T., HOFHAUS, G., & PREIS, D. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb15945.x · Cited by 499
Self-citationSmith, A. L. (1967) · Methods in Enzymology · doi:10.1016/0076-6879(67)10016-5 · Cited by 461
The Gene Locus of the Proton-translocating NADH : Ubiquinone Oxidoreductase in Escherichia coli
Weidner, U., Geier, S., Ptock, A., Friedrich, T., Leif, H., & Weiss, H. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1488 · Cited by 331
Self-citationFearnley, I. M., & Walker, J. E. (1992) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(92)90001-i · Cited by 311
NADH-ubiquinone oxidoreductases of the Escherichia coli aerobic respiratory chain
Matsushita, K., Ohnishi, T., & Kaback, H. R. (1987) · Biochemistry · doi:10.1021/bi00398a029 · Cited by 266
Self-citationMechanism of the neurotoxicity of MPTP: An update
(1990) · FEBS Letters · doi:10.1016/0014-5793(90)81315-f · Cited by 199
de VRIES, S., & GRIVELL, L. A. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb14292.x · Cited by 195
Photolabelling of a mitochondrially encoded subunit of NADH dehydrogenase with [3H]dihydrorotenone
Earley, F. G. P., Patel, S. D., RAGAN, C. I., & Attardi, G. M. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)81200-0 · Cited by 184
Cited by
Myxobacterial secondary metabolites: bioactivities and modes-of-action
Weissman, K. J., & Müller, R. (2010) · Natural Product Reports · doi:10.1039/c001260m · Cited by 310
A Possible Site of Superoxide Generation in the Complex I Segment of Rat Heart Mitochondria
Ohnishi, S. T., Ohnishi, T., Muranaka, S., Fujita, H., Kimura, H., Uemura, K., Yoshida, K.-I., & Utsumi, K. (2005) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-005-4117-y · Cited by 123
Self-citationMembers, E. W. E., Terron, A., Bal-Price, A., Paini, A., Monnet-Tschudi, F., Bennekou, S. H., Leist, M., & Schildknecht, S. (2018) · Archives of Toxicology · doi:10.1007/s00204-017-2133-4 · Cited by 124
Darrouzet, E., Issartel, J.-P., Lunardi, J., & Dupuis, A. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00719-4 · Cited by 122
Metadata
- Authors
- FRIEDRICH, T., VAN HEEK, P., LEIF, H., OHNISHI, T., FORCHE, E., KUNZE, B., JANSEN, R., TROWITZSCH‐KIENAST, W., HÖFLE, G., REICHENBACH, H., & WEISS, H.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1994-01
- Volume
- 219
- Issue
- 1-2
- Pages
- 691-698
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W1570597278
- Cited by
- 253
- References
- 22
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Two binding sites of inhibitors in NADH:ubiquinone oxidoreductase (complex I): Relationship of one site with the ubiquinone‐binding site of bacterial glucose:ubiquinone oxidoreductase. https://app.cochat.ai/papers/10.1111/j.1432-1033.1994.tb19985.x
- The paper
- FRIEDRICH, T., VAN HEEK, P., LEIF, H., OHNISHI, T., FORCHE, E., KUNZE, B., JANSEN, R., TROWITZSCH‐KIENAST, W., HÖFLE, G., REICHENBACH, H., & WEISS, H. (1994). Two binding sites of inhibitors in NADH:ubiquinone oxidoreductase (complex I): Relationship of one site with the ubiquinone‐binding site of bacterial glucose:ubiquinone oxidoreductase. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1994.tb19985.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
