The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Molecular Map of the Interactions between Titin and Myosin‐Binding Protein C: Implications for Sarcomeric Assembly in Familial Hypertrophic Cardiomyopathy
Open accessAbstract
The thick filaments of vertebrate striated muscles contain with myosin a number of accessory proteins of the intracellular immunoglobulin superfamily, which are localized in a distinct pattern of stripes 43 nm apart. The specific localization of these proteins is believed to be due partly to their interaction with the giant muscle protein titin (also called connectin), which spans the entire sarcomere and may act as a molecular ruler. We have used recombinant fragments of titin covering the thick filament region to investigate their interaction with myosin‐binding protein C (MyBP‐C) from skeletal and cardiac muscle. The interaction of titin and MyBP‐C is directed by a subset of titin immunoglobulin domains that are specific for the C‐region of the thick filament, supporting the ruler hypothesis for the myosin‐binding proteins. The interaction of recombinant titin with overlapping fragments of human cardiac MyBP‐C maps the titin‐binding site within the C‐terminal region, which is deleted in patients suffering from the chromosome‐11–associated form of familial hypertrophic cardiomyopathy. This disorder is therefore likely to be the result of thick‐filament misassembly by abolishing the ternary interaction of titin, myosin and MyBP‐C.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
Cited by
Hackman, P., Vihola, A., Haravuori, H., Marchand, S., Sarparanta, J., de Seze, J., Labeit, S., Witt, C., Peltonen, L., Richard, I., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342380 · Cited by 473
Familial Hypertrophic Cardiomyopathy: From Mutations to Functional Defects
Bonne, G., Carrier, L., Richard, P., Hainque, B., & Schwartz, K. (1998) · Circulation Research · doi:10.1161/01.res.83.6.580 · Cited by 425
Carrier, L., Bonne, G., Bahrend, E., Yu, B., Richard, P., Niel, F., Hainque, B., Cruaud, C., Gary, F., Labeit, S., et al. (1997) · Circulation Research · doi:10.1161/01.res.0000435859.24609.b3 · Cited by 302
Dhandapany, P. S., Sadayappan, S., Xue, Y., Powell, G. T., Rani, D. S., Nallari, P., Rai, T. S., Khullar, M., Soares, P., Bahl, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.309 · Cited by 286
Cardiac Titin: A Multifunctional Giant
LeWinter, M. M., & Granzier, H. (2010) · Circulation · doi:10.1161/circulationaha.109.860171 · Cited by 264
Metadata
- Authors
- Freiburg, A., & Gautel, M.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1996-01
- Volume
- 235
- Issue
- 1-2
- Pages
- 317-323
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W2084087656
- Cited by
- 278
- References
- 1
- FWCI
- 13.30
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Molecular Map of the Interactions between Titin and Myosin‐Binding Protein C: Implications for Sarcomeric Assembly in Familial Hypertrophic Cardiomyopathy. https://app.cochat.ai/papers/10.1111/j.1432-1033.1996.00317.x
- The paper
- Freiburg, A., & Gautel, M. (1996). A Molecular Map of the Interactions between Titin and Myosin‐Binding Protein C: Implications for Sarcomeric Assembly in Familial Hypertrophic Cardiomyopathy. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1996.00317.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
