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A Nonribosomal System of Peptide Biosynthesis
Open accessAbstract
This review covers peptide structures originating from the concerted action of enzyme systems without the direct participation of nucleic acids. Biosynthesis proceeds by formation of linear peptidyl intermediates which may be enzymatically modified as well as transformed into specific cyclic structures. The respective enzyme systems are constructed of biosynthetic modules integrated into multienzyme structures. Genetic and DNA‐sequence analysis of biosynthetic gene clusters have revealed extensive similarities between prokaryotic and eukaryotic systems, conserved principles of organisation, and a unique mechanism of transport of intermediates during elongation and modification steps involving 4′‐phospho‐pantetheine. These similarities permit the identification of peptide synthetases and related aminoacyl‐ligases and acyl‐ligases from sequence data. Similarities to other biosynthetic systems involved in the assembly of polyketide metabolites are discussed.
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Citations
Cited by
Polyketide biosynthesis: a millennium review
Staunton, J., & Weissman, K. J. (2001) · Natural Product Reports · doi:10.1039/a909079g · Cited by 1,641
Seebach, D., Beck, A. K., & Bierbaum, D. J. (2004) · Chemistry & Biodiversity · doi:10.1002/cbdv.200490087 · Cited by 932
Quadri, L. E. N., Weinreb, P. H., Lei, M., Nakano, M. M., Zuber, P., & Walsh, C. T. (1998) · Biochemistry · doi:10.1021/bi9719861 · Cited by 693
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Nakatsu, T., Ichiyama, S., Hiratake, J., Saldanha, A., Kobashi, N., Sakata, K., & Kato, H. (2006) · Nature · doi:10.1038/nature04542 · Cited by 517
Haas, H. (2003) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1335-2 · Cited by 334
Metadata
- Authors
- Kleinkauf, H., & Von Döhren, H.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1996-03
- Volume
- 236
- Issue
- 2
- Pages
- 335-351
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W2019367914
- Cited by
- 344
- References
- 0
- FWCI
- 27.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kleinkauf, H., & Von Döhren, H. (1996). A Nonribosomal System of Peptide Biosynthesis. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1996.00335.x
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