The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The impact of disease recurrence on graft survival following liver transplantation: a single centre experience
Open accessAbstract
Many diseases that cause liver failure may recur after transplantation. A retrospective analysis of the rate and cause of graft loss of 1840 consecutive adults receiving a primary liver transplant between 1982 and 2004 was performed to evaluate the rate of graft loss from disease recurrence. The risk of graft loss from recurrent disease was greatest, when compared to primary biliary cirrhosis (PBC), in those transplanted for hepatitis C virus (HCV) [hazard ratio (HR) 11.6; 95% confidence interval (CI) 5.1-26.6], primary sclerosing cholangitis (PSC) (HR 6.0; 95% CI 2.5-14.2) and autoimmune hepatitis (AIH) (HR 4.1; 95% CI 1.3-12.6). The overall risk of graft loss was also significantly greater in HCV (HR 2.1 vs. PBC; 95% CI 1.5-3.0), PSC (HR 1.6 vs. PBC; 95% CI 1.2-2.3) and AIH (HR 1.6; 95% CI 1.0-2.4) than in PBC. There was no statistically significant difference in the risk of graft loss because of recurrent disease, when compared with PBC, for patients transplanted for alcohol related liver disease, nonalcoholic steatohepatitis and fulminant hepatic failure. Disease recurrence is a significant cause of graft loss particularly in HCV, PSC and AIH. Recurrent disease, in part, explains the increased overall risk of graft loss in these groups.
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Cites
Charatcharoenwitthaya, P., Pimentel, S., Talwalkar, J. A., Enders, F. T., Lindor, K. D., Krom, R. A. F., & Wiesner, R. H. (2007) · Liver Transplantation · doi:10.1002/lt.21124 · Cited by 179
Neuberger, J., Gunson, B., Hubscher, S., & Nightingale, P. (2004) · Liver Transplantation · doi:10.1002/lt.20123 · Cited by 155
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Cited by
Martin, P., DiMartini, A., Feng, S., Brown, R., & Fallon, M. (2014) · Hepatology · doi:10.1002/hep.26972 · Cited by 1,045
Natural history of hepatitis C.
Westbrook, R. H., & Dusheiko, G. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.07.012 · Cited by 1,049
Burra, P., Senzolo, M., Adam, R., Delvart, V., Karam, V., Germani, G., & Neuberger, J. (2010) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02869.x · Cited by 335
Self-citationAlabraba, E., Nightingale, P., Gunson, B., Hubscher, S., Olliff, S., Mirza, D., & Neuberger, J. (2009) · Liver Transplantation · doi:10.1002/lt.21679 · Cited by 298
Self-citationAutoimmune liver disease, autoimmunity and liver transplantation
Carbone, M., & Neuberger, J. M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.09.020 · Cited by 250
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Metadata
- Authors
- Rowe, I. A., Webb, K., Gunson, B. K., Mehta, N., Haque, S., & Neuberger, J.
- Venue
- Transplant International
- Publisher
- Frontiers Media SA
- Published
- 2008-05
- Volume
- 21
- Issue
- 5
- Pages
- 459-465
- ISSN
- 0934-0874 (ISSN-L)
- 1432-2277
- OpenAlex
- W2120070121
- Cited by
- 199
- References
- 2
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rowe, I. A., Webb, K., Gunson, B. K., Mehta, N., Haque, S., & Neuberger, J. (2008). The impact of disease recurrence on graft survival following liver transplantation: a single centre experience. Transplant International. https://doi.org/10.1111/j.1432-2277.2007.00628.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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