The spectrum of nonadherence with medication in heart, liver, and lung tranplant patients assessed in various ways: Nonadherence in transplant patients
Abstract
Adherence to medication regimes is crucial for transplant patients. Addressing methodological limitations and gaps in the literature, we studied: (i) the prevalence of nonadherence (NA) with immunosuppression (IS) using various measurement methods, (ii) NA prevalence regarding intake and timing, (iii) changes in NA over time, (iv) differences in NA across organ transplant populations, (v) NA regarding co-medication. Using a descriptive, prospective, comparative design over 3 months, we included convenience samples of adult heart (n=79), liver (n=55), and lung (n=104) transplant patients. NA with IS was measured using self-report, collateral report, blood assay, electronic monitoring (Helping Hand™ , Bang and Olufsen Medicom, Denmark), and their combinations. In the overall sample, depending on the method used, IS NA ranged from 23.9% to 70.0%. For co-medication, the overall NA rate was 30.1% using self-report. Nonadherence rates remained stable over time. At inclusion, significant NA differences between organ groups were reported via self- and collateral report; lung transplant patients were less adherent than heart or liver transplant recipients, both to IS and to co-medication.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
De Geest's group suggested a combined assessment of patients' self-reports, clinicians' estimates, and blood levels.
“De Geest’s group suggested a combined assessment of patients’ self-reports, clinicians’ estimates, and blood levels[40].”
From Adherence is associated with a favorable outcome after lung transplantation (2019) · cites this paper as [40]
Cites
Osterberg, L., & Blaschke, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050100 · Cited by 7,974 · see citing works
Interventions for enhancing medication adherence
Nieuwlaat, R., Wilczynski, N., Navarro, T., Hobson, N., Jeffery, R., Keepanasseril, A., Agoritsas, T., Mistry, N., Iorio, A., Jack, S., et al. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub4 · Cited by 2,945 · see citing works
Interventions for enhancing medication adherence
Haynes, R. B., Ackloo, E., Sahota, N., McDonald, H. P., & Yao, X. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub3 · Cited by 1,244 · see citing works
Farmer, K. C. (1999) · Clinical Therapeutics · doi:10.1016/s0149-2918(99)80026-5 · Cited by 889 · see citing works
Dobbels, F., Berben, L., De Geest, S., Drent, G., Lennerling, A., Whittaker, C., & Kugler, C. (2010) · Transplantation · doi:10.1097/tp.0b013e3181e346cd · Cited by 220 · see citing works
Self-citationTakemoto, S. K., Pinsky, B. W., Schnitzler, M. A., Lentine, K. L., Willoughby, L. M., Burroughs, T. E., & Bunnapradist, S. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.01966.x · Cited by 202 · cited 1× · see citing works
“First, the majority use a single NA measurement method; in the absence of a gold standard to assess medication NA, recent studies recommend a combination of assessment methods to enhance sensitivity [4,5].”
Method
Flagged first, then by citations
Cited by
Sorted by citations
Medication Nonadherence After Lung Transplantation in Adult Recipients
Castleberry, A. W., Bishawi, M., Worni, M., Erhunmwunsee, L., Speicher, P. J., Osho, A. A., Snyder, L. D., & Hartwig, M. G. (2017) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2016.06.067 · Cited by 39 · see citing works
Adherence is associated with a favorable outcome after lung transplantation
Bertram, A., Fuge, J., Suhling, H., Tudorache, I., Haverich, A., Welte, T., & Gottlieb, J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226167 · Cited by 34 · see citing works
- Authors
- De Bleser, L., Dobbels, F., Berben, L., Vanhaecke, J., Verleden, G., Nevens, F., & De Geest, S.
- Affiliations
- KU Leuven (BE)
- University of Basel (CH)
- Universitair Ziekenhuis Leuven (BE)
- Venue
- Transplant International
- Publisher
- Frontiers Media SA
- Published
- 2011-07-11
- Volume
- 24
- Issue
- 9
- Pages
- 882-891
- ISSN
- 0934-0874 (ISSN-L)
- OpenAlex
- W1525381244
- Cited by
- 89
- References
- 6
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 11 · 2016: 5 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 3
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transplant International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
- Keywords
- medication non-adherence, immunosuppression, heart transplantation, liver transplantation, lung transplantation, concomitant medications, electronic medication monitoring, self-report, collateral reports, adherence measurement methods, organ transplant recipients
- MeSH terms
- Assessment of Medication Adherence, Aged, Drug Therapy, Combination, Female, Humans, Immunosuppression Therapy, Immunosuppressive Agents, Male, Middle Aged, Prospective Studies, Self Disclosure, Prevalence, Heart Transplantation, Liver Transplantation, Lung Transplantation, Tacrolimus, Drug Monitoring, Medication Adherence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
