Predictive value of semen parameters in in vitro fertilisation pregnancy outcome
Open accessAbstract
This study investigated retrospectively the predictive value of routine semen analysis in pregnancy by in vitro fertilisation (IVF). The selected (n = 796) cycles were divided into two groups: pregnancy group (group 1; n = 264) and nonpregnancy group (group 2; n = 532), in which the female partners were normal or just had tube problems. No significant differences were found in the percentage of normal sperm morphology, sperm motility, sperm progressive motility, rapid progressive motility (rapid) and concentration between the two groups (P > 0.05). However, teratozoospermic index (TZI) and sperm deformity index (SDI) showed statistically significant differences between the two groups (P < 0.05). The number of retrieved eggs (P = 0.001), fertilisation rate (P = 0.000) and number of embryos transferred (P = 0.020) in group 1 were significantly higher than those in group 2, but no significant differences were noted in cleavage rates, and good quality embryo rates between the two groups (P > 0.05). Using receiver operating characteristics curve, we found that semen parameters (morphology, motility and concentration), fertilisation rate, TZI and SDI were not good indicators for pregnancy by IVF. Thus, the semen parameters evaluated according to criteria of the World Health Organization are no good predictors for accurately identifying the IVF outcome. However, TZI and SDI may be more informative than other semen parameters.
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Analysis of ROC curves showed that sperm abnormality indexes had no predictive value for the outcome of IVF.
“Nevertheless, analysis of ROC curves showed that these indexes had no predictive value for the outcome of IVF [73].”
From Recommendations for Human Sperm Morphology Assessment in 2025: An Expert Review From the French BLEFCO Group (2026) · cites this paper as [73]
The Results say ROC analysis found TZI and SDI were not good indicators of IVF pregnancy, with AUCs below 0.6. But the claim’s “no predictive value” is stronger than the paper’s conclusion of poor predictive value: the Abstract also reports significant differences in both indexes between pregnancy groups and says they may be more informative than other semen parameters. (LLM, conf=0.86)
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Research works printed but not linked: 3
- Coetzee K, Kruge TF, Lombard CJ (1998) Predictive value of normal sperm morphology: a structured literature review. Hum Reprod Update 4:73-82.
- DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Compar- ing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837-845.
- World Health Organization (1999) WHO Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. Cambridge University Press, Cambridge.
Cited by
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Gatimel, N., Barbotin, A., Mery, L., Beauvillard, D., Bendayan, M., Boursier, A., Boueilh, T., Pereira, B., Chammas, J., Jacquet, J., et al. (2026) · Andrology · doi:10.1111/andr.70134 · Cited by 2 · see citing works
- Authors
- Chen, X., Zhang, W., Luo, Y., Long, X., & Sun, X.
- Affiliations
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Corresponding author
- Chen, X.
- Venue
- Andrologia
- Publisher
- Hindawi Limited
- Published
- 2009-04
- Volume
- 41
- Issue
- 2
- Pages
- 111-117
- ISSN
- 0303-4569 (ISSN-L)
- 1439-0272
- OpenAlex
- W2012982369
- Cited by
- 27
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 3 · 2021: 2 · 2018: 5 · 2017: 2 · 2016: 3 · 2013: 3 · 2012: 2
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Andrologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- semen parameters, in vitro fertilization, pregnancy outcome prediction, sperm morphology, sperm motility, sperm concentration, fertilization rate, embryo quality
- MeSH terms
- Adult, Female, Fertilization in Vitro, Humans, Infertility, Male, Male, Predictive Value of Tests, Pregnancy, Pregnancy Outcome, Retrospective Studies, ROC Curve, Semen Analysis
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