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Cited by 23Parasitic infections in humans and animalsParasites and Host InteractionsParasitic Infections and Diagnostics

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Dual treatment of albendazole in hepatic hydatidosis: New therapeutic modality in 52 cases

POLAT, CAFER, DERVISOGLU, ADEM, HOKELEK, MURAT, YETIM, IBRAHIM, BUYUKKARABACAK, YALCIN, OZKUTUK, YASIN, ERZURUMLU, KENAN·2005·Journal of Gastroenterology and Hepatology
DOI 10.1111/j.1440-1746.2004.03535.x
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Abstract

Background: Hepatic hydatidosis still remains as a serious problem in general surgery. Recurrence and/or secondary hydatidosis rates are up to 25% in the cases treated with surgery alone. Albendazole is the most commonly used drug in the medical treatment of echinococcosis. The aim of the present study was to evaluate the effect of albendazole using the intraoperative and perioperative periods as dual therapy. Methods: Fifty‐two cases of hepatic hydatidosis were evaluated and treated by dual treatment of albendazole together with surgery. Perioperative albendazole treatment was given in a dose of 12–15 mg/kg per day in four divided doses. The treatment started 2–28 days before the surgery when the diagnosis was established and continued for 2–24 months (4.76 ± 3.25) postoperatively in a cyclic monthly form. A total of 1.7 µg/mL albendazole solution was used as a protoscolicidal agent in the cystic cavity intraoperatively. In the postoperative period serology, ultrasonography and computed tomography evaluations were done. The follow‐up period was 5–92 months (mean: 62.48 months). Results: There was no recurrence in the present study. One patient died in the 6th postoperative week due to cerebral hydatidosis and multiple organ failure. Early and late morbidity rates were 7.69 and 9.61%, respectively. Conclusions: Dual albendazole treatment is effective in the prevention of recurrences and/or secondary hydatidosis.

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  • Most problems with albendazole are associated with higher dose treatment for systemic infections where drug-parasite interactions cause specific syndromes such as abnormal liver functions, central nervous system symptoms, or hematologic side effects.

    “Most problems are associated with higher dose treatment for systemic infections where problems of drug-parasite interactions cause specific syndromes such as abnormal liver functions (for example, in echinococcosis), central nervous system symptoms (in neurocysticercosis), or hematologic side effects [53,308–312].”

    From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [311]

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Metadata

Authors
POLAT, C., DERVISOGLU, A., HOKELEK, M., YETIM, I., BUYUKKARABACAK, Y., OZKUTUK, Y., & ERZURUMLU, K.
Affiliations
Ondokuz Mayıs University (TR)
Corresponding author
POLAT, CAFER
ORCID
Venue
Journal of Gastroenterology and Hepatology
Publisher
Wiley
Published
2005-02-24
Volume
20
Issue
3
Pages
421-425
ISSN
  • 0815-9319 (ISSN-L)
  • 1440-1746
DOI
10.1111/j.1440-1746.2004.03535.x
OpenAlex
W2059936196
Cited by
23
References
0
Citations by year
2025: 1 · 2023: 3 · 2021: 2 · 2019: 1 · 2016: 1 · 2014: 5 · 2013: 1 · 2012: 3
FWCI
0.89
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Gastroenterology and Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic infections in humans and animals
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
Keywords
hepatic hydatidosis, echinococcosis, albendazole, perioperative chemotherapy, recurrence prevention, postoperative follow-up, surgical treatment
MeSH terms
Adult, Aged, Anticestodal Agents, Combined Modality Therapy, Drug Administration Routes, Echinococcosis, Hepatic, Female, Follow-Up Studies, Humans, Intraoperative Period, Male, Middle Aged, Laparoscopy, Postoperative Period, Retrospective Studies, Suction, Video Recording, Albendazole, Treatment Outcome, Perioperative Care

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